1-Azabicyclo [2.2.2]octan-3-yl 2-Hydroxy-3-(4-morpholinyl)-2-phenylpropionate

Base Information

• Chemical Name: 1-Azabicyclo [2.2.2]octan-3-yl 2-Hydroxy-3-(4-morpholinyl)-2-phenylpropionate
• CAS No.: 122846-65-5
• Molecular Formula: C₂₀H₂₈N₂O₄
• Molecular Weight: 360.453

Synonyms:1-Azabicyclo [2.2.2]octan-3-yl 2-Hydroxy-3-(4-morpholinyl)-2-phenylpropionate

Chemical Property of 1-Azabicyclo [2.2.2]octan-3-yl 2-Hydroxy-3-(4-morpholinyl)-2-phenylpropionate

Chemical Property:

Purity/Quality:

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Technology Process of 1-Azabicyclo [2.2.2]octan-3-yl 2-Hydroxy-3-(4-morpholinyl)-2-phenylpropionate

There total 3 articles about 1-Azabicyclo [2.2.2]octan-3-yl 2-Hydroxy-3-(4-morpholinyl)-2-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.4%

→ 1-Azabicyclo [2.2.2]octan-3-yl 2-Hydroxy-3-(4-morpholinyl)-2-phenylpropionate (122846-65-5)

Guidance literature:

Reference yield:

ethyl α-phenylglycidate (19780-36-0) → 1-Azabicyclo [2.2.2]octan-3-yl 2-Hydroxy-3-(4-morpholinyl)-2-phenylpropionate (122846-65-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 63.2 percent / ethanol / 18 h / Heating

2: 1.) Na / 1.) benzene, reflux, 1 h, 2.) reflux, 18 h

With sodium; In ethanol;

DOI:10.1021/jm00163a050

Reference yield:

ethyl 2-hydroxy-3-(4-morpholinyl)-2-phenylpropionate (122846-56-4) + 3-quinuclidinol (1619-34-7) → 1-Azabicyclo [2.2.2]octan-3-yl 2-Hydroxy-3-(4-morpholinyl)-2-phenylpropionate (122846-65-5)

Guidance literature:

With sodium; Yield given. Multistep reaction; 1.) benzene, reflux, 1 h, 2.) reflux, 18 h;

DOI:10.1021/jm00163a050

upstream raw materials:

ethyl 2-hydroxy-3-(4-morpholinyl)-2-phenylpropionate

3-quinuclidinol

ethyl α-phenylglycidate

Downstream raw materials:

3-(1-methyl-1-azabicyclo<2.2.2>octyl) 2-hydroxy-3-(4-morpholinyl)-2-phenylpropionate iodide

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