2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridine-3-carbaldehyde oxime

Base Information

Chemical Name:2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridine-3-carbaldehyde oxime
CAS No.:1435395-62-2
Molecular Formula:C₁₅H₁₂FN₃O
Molecular Weight:269.278
Hs Code.:

Synonyms:2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridine-3-carbaldehyde oxime

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Chemical Property of 2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridine-3-carbaldehyde oxime

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Technology Process of 2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridine-3-carbaldehyde oxime

There total 4 articles about 2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridine-3-carbaldehyde oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 727652-03-1
2-(4-fluorophenyl)-8-methylimidazo[1,2-a]pyridine-3-carbaldehyde

: 1435395-62-2
2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridine-3-carbaldehyde oxime

Guidance literature:: With sulfuric acid; hydroxylamine hydrochloride; In ethanol; for 4h; Reflux;
DOI:10.1016/j.bmcl.2013.03.086

Reference yield:

: 380873-23-4
2-(4-fluorophenyl)-8-methylimidazo[1,2-a]pyridine

: 1435395-62-2
2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridine-3-carbaldehyde oxime

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 0 - 5 °C

1.2: 6 h / 80 °C

2.1: hydroxylamine hydrochloride; sulfuric acid / ethanol / 4 h / Reflux

With sulfuric acid; hydroxylamine hydrochloride; trichlorophosphate; In ethanol; 1.1: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.bmcl.2013.03.086

Reference yield:

: 1603-40-3
3-methylpyridin-2-ylamine

: 1435395-62-2
2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridine-3-carbaldehyde oxime

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 6 h / Reflux

2.1: trichlorophosphate / 0 - 5 °C

2.2: 6 h / 80 °C

3.1: hydroxylamine hydrochloride; sulfuric acid / ethanol / 4 h / Reflux

With sulfuric acid; hydroxylamine hydrochloride; trichlorophosphate; In ethanol; 2.1: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.bmcl.2013.03.086