morpholine-4-carboxylic acid 4-nitrophenyl ester

Base Information

• Chemical Name: morpholine-4-carboxylic acid 4-nitrophenyl ester
• CAS No.: 17376-42-0
• Molecular Formula: C₁₁H₁₂N₂O₅
• Molecular Weight: 252.227
• Mol file: 17376-42-0.mol

Synonyms:morpholine-4-carboxylic acid 4-nitrophenyl ester

Chemical Property of morpholine-4-carboxylic acid 4-nitrophenyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

4-NITROPHENYL MORPHOLINE-4-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of morpholine-4-carboxylic acid 4-nitrophenyl ester

There total 4 articles about morpholine-4-carboxylic acid 4-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + 4-Nitrophenyl chloroformate (7693-46-1) → morpholine-4-carboxylic acid 4-nitrophenyl ester (17376-42-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3.5h;

Reference yield:

morpholine (110-91-8,99108-56-2) + O‐(4‐cyanophenyl) O‐(4‐nitrophenyl) carbonate → morpholine-4-carboxylic acid 4-nitrophenyl ester (17376-42-0) + 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + 4-cyanophenyl 4-morpholinecarboxylate + 4-cyanophenol (767-00-0)

Guidance literature:

In acetonitrile; at 25 ℃; Solvent; Kinetics;

DOI:10.1039/d0nj05837h

Reference yield:

4-morpholinocarbonyl chloride (15159-40-7) + 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → morpholine-4-carboxylic acid 4-nitrophenyl ester (17376-42-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 12h;

DOI:10.1021/jacs.9b02751

upstream raw materials:

morpholine

4-Nitrophenyl chloroformate

4-morpholinocarbonyl chloride

4-nitro-phenol

Refernces

• 1、 Nishizawa, Akihiro,Takahira, Tsuyoshi,Yasui, Kosuke,Fujimoto, Hayato,Iwai, Tomohiro,Sawamura, Masaya,Chatani, Naoto,Tobisu, Mamoru. "Nickel-Catalyzed Decarboxylation of Aryl Carbamates for Converting Phenols into Aromatic Amines". supporting information. p. 7261 - 7265. Retrieved 2019/05/16.
• 2、 -. "Substituted heteroaryl compounds and composition thereof, and applicaitons of compounds and composition". Paragraph 0882; 0883; 0884; 0885. . Retrieved 2017/07/31.