N-[(2,2-dimethyl-3-hydroxy)propyl]-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-[(2,2-dimethyl-3-hydroxy)propyl]-4-methylbenzenesulfonamide
• CAS No.: 718633-46-6
• Molecular Formula: C₁₂H₁₉NO₃S
• Molecular Weight: 257.354
• Mol file: 718633-46-6.mol

Synonyms:N-[(2,2-dimethyl-3-hydroxy)propyl]-4-methylbenzenesulfonamide

Chemical Property of N-[(2,2-dimethyl-3-hydroxy)propyl]-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(2,2-dimethyl-3-hydroxy)propyl]-4-methylbenzenesulfonamide

There total 2 articles about N-[(2,2-dimethyl-3-hydroxy)propyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

3-amino-2,2-dimethylpropan-1-ol (26734-09-8) + p-toluenesulfonyl chloride (98-59-9) → N-[(2,2-dimethyl-3-hydroxy)propyl]-4-methylbenzenesulfonamide (718633-46-6)

Guidance literature:

With sodium carbonate; In water; for 6.5h;

DOI:10.1021/jo030360f

Reference yield:

2-cyano-2-methyl-propionic acid ethyl ester (1572-98-1) → N-[(2,2-dimethyl-3-hydroxy)propyl]-4-methylbenzenesulfonamide (718633-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 48 h / Reflux

2: triethylamine / dichloromethane / 12 h / 0 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1002/adsc.201300982

Reference yield: 90.0%

1-bromo-4-butene (5162-44-7) + N-[(2,2-dimethyl-3-hydroxy)propyl]-4-methylbenzenesulfonamide (718633-46-6) → N-(but-3-en-1-yl)-N-(3-hydroxy-2,2-dimethylpropyl)-4-methylbenzenesulfonamide

Guidance literature:

N-[(2,2-dimethyl-3-hydroxy)propyl]-4-methylbenzenesulfonamide; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

1-bromo-4-butene; In N,N-dimethyl-formamide; at 80 ℃; for 16h; Inert atmosphere;

DOI:10.1039/d1cc04056a

upstream raw materials:

3-amino-2,2-dimethylpropan-1-ol

p-toluenesulfonyl chloride

2-cyano-2-methyl-propionic acid ethyl ester