4-((4-(4-([1,1′-biphenyl]-3-yl)-1H-1,2,3-triazol-1-yl)phenyl)sulfonyl)-N-hydroxypiperidine-4-carboxamide hydrochloride

Base Information

• Chemical Name: 4-((4-(4-([1,1′-biphenyl]-3-yl)-1H-1,2,3-triazol-1-yl)phenyl)sulfonyl)-N-hydroxypiperidine-4-carboxamide hydrochloride
• CAS No.: 1458220-73-9
• Molecular Formula: C₂₆H₂₅N₅O₄S
• Molecular Weight: 503.582

Synonyms:4-((4-(4-([1,1′-biphenyl]-3-yl)-1H-1,2,3-triazol-1-yl)phenyl)sulfonyl)-N-hydroxypiperidine-4-carboxamide hydrochloride

Chemical Property of 4-((4-(4-([1,1′-biphenyl]-3-yl)-1H-1,2,3-triazol-1-yl)phenyl)sulfonyl)-N-hydroxypiperidine-4-carboxamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((4-(4-([1,1′-biphenyl]-3-yl)-1H-1,2,3-triazol-1-yl)phenyl)sulfonyl)-N-hydroxypiperidine-4-carboxamide hydrochloride

There total 10 articles about 4-((4-(4-([1,1′-biphenyl]-3-yl)-1H-1,2,3-triazol-1-yl)phenyl)sulfonyl)-N-hydroxypiperidine-4-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 4-((4-(4-([1,1′-biphenyl]-3-yl)-1H-1,2,3-triazol-1-yl)-phenyl)sulfonyl)-4-(((tetrahydro-2H-pyran-2-yl)oxy)carbamoyl)-piperidine-1-carboxylate → 4-((4-(4-([1,1′-biphenyl]-3-yl)-1H-1,2,3-triazol-1-yl)phenyl)sulfonyl)-N-hydroxypiperidine-4-carboxamide hydrochloride (1458220-73-9)

Guidance literature:

With hydrogenchloride; methanol; In 1,4-dioxane; at 20 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1039/c3ob41046c

Reference yield:

1-tert-butyl 4-ethyl 4-((4-nitrophenyl)sulfanyl)piperidine-1,4-dicarboxylate (1438386-11-8) → 4-((4-(4-([1,1′-biphenyl]-3-yl)-1H-1,2,3-triazol-1-yl)phenyl)sulfonyl)-N-hydroxypiperidine-4-carboxamide hydrochloride (1458220-73-9)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium hydroxide; water / ethanol / 48 h / 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

3.1: palladium; hydrogen / ethanol / 72 h / 20 °C / 3102.97 Torr

4.1: trimethylsilylazide; tert.-butylnitrite / acetonitrile / 2.5 h / 0 - 20 °C / Inert atmosphere

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 20 °C

6.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

7.1: hydrogenchloride; methanol / 1,4-dioxane / 0.33 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; methanol; tert.-butylnitrite; copper(ll) sulfate pentahydrate; trimethylsilylazide; water; hydrogen; benzotriazol-1-ol; palladium; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1039/c3ob41046c

Reference yield:

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate (142851-03-4) → 4-((4-(4-([1,1′-biphenyl]-3-yl)-1H-1,2,3-triazol-1-yl)phenyl)sulfonyl)-N-hydroxypiperidine-4-carboxamide hydrochloride (1458220-73-9)

Guidance literature:

Multi-step reaction with 8 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 - 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / ethanol / 48 h / 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

4.1: palladium; hydrogen / ethanol / 72 h / 20 °C / 3102.97 Torr

5.1: trimethylsilylazide; tert.-butylnitrite / acetonitrile / 2.5 h / 0 - 20 °C / Inert atmosphere

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.17 h / 20 °C

6.2: 20 °C

7.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

8.1: hydrogenchloride; methanol / 1,4-dioxane / 0.33 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; methanol; tert.-butylnitrite; copper(ll) sulfate pentahydrate; trimethylsilylazide; water; hydrogen; benzotriazol-1-ol; palladium; sodium L-ascorbate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1039/c3ob41046c

upstream raw materials:

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

1-tert-butyl 4-ethyl 4-((4-nitrophenyl)sulfanyl)piperidine-1,4-dicarboxylate

1-(tert-butoxycarbonyl)-4-(4-nitrophenylthio)piperidine-4-carboxylic acid

1-(tert-butoxycarbonyl)-4-(4-nitrophenylsulfonyl)piperidine-4-carboxylic acid

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