2-(4-(hydroxymethyl)-2-methoxyphenoxy)ethanol

Base Information

Chemical Name:2-(4-(hydroxymethyl)-2-methoxyphenoxy)ethanol
CAS No.:936478-21-6
Molecular Formula:C₁₀H₁₄O₄
Molecular Weight:198.219
Hs Code.:

Synonyms:2-(4-(hydroxymethyl)-2-methoxyphenoxy)ethanol

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Chemical Property of 2-(4-(hydroxymethyl)-2-methoxyphenoxy)ethanol

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Technology Process of 2-(4-(hydroxymethyl)-2-methoxyphenoxy)ethanol

There total 8 articles about 2-(4-(hydroxymethyl)-2-methoxyphenoxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 64673-04-7
3-methoxy-4-(2-hydroxyethoxy)benzaldehyde

: 936478-21-6
2-(4-(hydroxymethyl)-2-methoxyphenoxy)ethanol

Guidance literature:: 4-(2-hydroxyethoxy)-3-methoxybenzaldehyde; With pyridinium p-toluenesulfonate; In 1,2-dichloro-ethane; at 80 ℃; for 20h;

With triethylamine; In dichloromethane; at 20 ℃; for 6h;

With trifluoroacetic acid; In methanol; dichloromethane; at 140 ℃; for 0.0666667h; Further stages.; microwave irradiation;
DOI:10.1021/jo0622173

Reference yield:

: 498-02-2
1-(3-methoxy-4-hydroxyphenyl)ethanone

: 936478-21-6
2-(4-(hydroxymethyl)-2-methoxyphenoxy)ethanol

Guidance literature:: Multi-step reaction with 8 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 70 °C

2: bromine / cyclohexane; dichloromethane; ethanol / 20 °C / Inert atmosphere

3: potassium carbonate / acetone / 2 h / Reflux

4: potassium carbonate / water; 1,4-dioxane / 20 °C

5: 5%-palladium/activated carbon; hydrogen / ethyl acetate; ethanol

6: 6,6′‐dihydroxyl‐2,2′‐bipyridine; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium carbonate / water; 1,4-dioxane / 1 h / 130 °C / Sealed tube

7: potassium carbonate / acetone / 14 h / Reflux

8: sodium tetrahydroborate; methanol / ethanol / 1.08 h / 50 °C

With methanol; sodium tetrahydroborate; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; 5%-palladium/activated carbon; hydrogen; bromine; sodium carbonate; potassium carbonate; 6,6′‐dihydroxyl‐2,2′‐bipyridine; In 1,4-dioxane; ethanol; dichloromethane; cyclohexane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1039/c8gc01366g

Reference yield:

: 22317-29-9
1-(4-(benzyloxy)-3-methoxyphenyl)-2-(2-methoxyphenoxy)ethan-1-one

: 936478-21-6
2-(4-(hydroxymethyl)-2-methoxyphenoxy)ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / water; 1,4-dioxane / 20 °C

2: 5%-palladium/activated carbon; hydrogen / ethyl acetate; ethanol

3: 6,6′‐dihydroxyl‐2,2′‐bipyridine; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium carbonate / water; 1,4-dioxane / 1 h / 130 °C / Sealed tube

4: potassium carbonate / acetone / 14 h / Reflux

5: sodium tetrahydroborate; methanol / ethanol / 1.08 h / 50 °C

With methanol; sodium tetrahydroborate; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; 5%-palladium/activated carbon; hydrogen; sodium carbonate; potassium carbonate; 6,6′‐dihydroxyl‐2,2′‐bipyridine; In 1,4-dioxane; ethanol; water; ethyl acetate; acetone;
DOI:10.1039/c8gc01366g