4-(2-Hydroxyethoxy)-3-methoxybenzaldehyde

Base Information

• Chemical Name: 4-(2-Hydroxyethoxy)-3-methoxybenzaldehyde
• CAS No.: 64673-04-7
• Molecular Formula: C10H12O4
• Molecular Weight: 196.203
• Hs Code.: 2912499000
• DSSTox Substance ID: DTXSID10390005
• Nikkaji Number: J1.607.602C
• Mol file: 64673-04-7.mol

Synonyms:4-(2-hydroxyethoxy)-3-methoxybenzaldehyde;64673-04-7;4-(2-Hydroxy-ethoxy)-3-methoxy-benzaldehyde;Benzaldehyde,4-(2-hydroxyethoxy)-3-methoxy-;SCHEMBL92184;DTXSID10390005;VGXGYHPTBPXION-UHFFFAOYSA-N;MFCD02256123;STK347841;AKOS000179342;4-(2-Hydroxyethoxy)3-methoxybenzaldehyde;3-Methoxy-4-(2-hydroxyethoxy)benzaldehyde;CS-0240345;EN300-227945;Z295453126

Chemical Property of 4-(2-Hydroxyethoxy)-3-methoxybenzaldehyde

Chemical Property:

• Vapor Pressure: 7.18E-06mmHg at 25°C
• Refractive Index: 1.557
• Boiling Point: 361.9 °C at 760 mmHg
• Flash Point: 144.4 °C
• PSA: 55.76000
• Density: 1.202 g/cm³
• LogP: 0.87880
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 196.07355886
• Heavy Atom Count: 14
• Complexity: 172

Purity/Quality:

98%min ^*data from raw suppliers

4-(2-Hydroxy-ethoxy)-3-methoxy-benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)C=O)OCCO

Technology Process of 4-(2-Hydroxyethoxy)-3-methoxybenzaldehyde

There total 12 articles about 4-(2-Hydroxyethoxy)-3-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

vanillin (121-33-5,8014-42-4) + 2-bromoethanol (540-51-2) → 3-methoxy-4-(2-hydroxyethoxy)benzaldehyde (64673-04-7)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 65 ℃; for 4h;

Reference yield: 75.0%

vanillin (121-33-5,8014-42-4) + 2-chloro-ethanol (107-07-3) → 3-methoxy-4-(2-hydroxyethoxy)benzaldehyde (64673-04-7)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; for 6h; Reflux;

DOI:10.1016/j.jorganchem.2018.06.007

Reference yield: 64.0%

2-(4-(hydroxymethyl)-2-methoxyphenoxy)ethanol (936478-21-6) → 3-methoxy-4-(2-hydroxyethoxy)benzaldehyde (64673-04-7)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; for 0.25h;

DOI:10.1039/c8gc01366g

upstream raw materials:

vanillin

2-chloro-ethanol

ethylene dibromide

2-bromoethanol

Downstream raw materials:

4-methylbenzenesulfonic acid [(4-formyl-2-methoxyphenoxy)ethyl] ester

C₁₆H₂₃NO₃

2-[4-(2-hydroxy-ethoxy)-3-methoxybenzylidene]-indan-1-one

3-methoxy-4-(2-(4-nitrobenzenesulfonyloxy)ethoxy)benzaldehyde

Refernces

• 1、 -. "Urea compound containing piperazine group, and preparation method and application thereof". Paragraph 0045; 0051-0052. . Retrieved 2021/08/25.
• 2、 Teimuri-Mofrad, Reza,Tahmasebi, Shabnam,Payami, Elmira. "Fe3O4@SiO2@Im-bisethylFc [HC2O4] as a novel recyclable heterogeneous nanocatalyst for synthesis of bis-coumarin derivatives". . . Retrieved 2019/04/26.