64673-04-7Relevant academic research and scientific papers
Substituted diaryl compound and preparation method and application thereof
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Paragraph 0068, (2021/09/15)
The invention relates to the field of medicinal chemistry, in particular to a substituted diaryl compound (I). The preparation method comprises the following steps: medicine preparation and medical application thereof. Test results show that the substituted diaryl compound has a good inhibition effect on human lung cancer (A549), human ovarian cancer (SKOV3), human melanoma (A375) and human colon cancer (LOVO) cells. Formula (I):
3 - (4 - Methylpiperidine -1 -yl) -3 -benzyl urea compound and the like. Preparation method and application
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Paragraph 0032; 0048-0050, (2021/08/25)
3 - (4 - Methylpiperi -1 -yl) -3 -benzyl urea compounds and analogs thereof, and a preparation method and application thereof belong to the technical field of medicines, and particularly relates to preparation of 3 - (4 - methylpiperi -1-yl) -3 - benzyl u
Urea compound containing piperazine group, and preparation method and application thereof
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Paragraph 0045; 0051-0052, (2021/08/25)
The invention belongs to the technical field of medicines, and particularly relates to 1 - aryl -3 - {3 - methoxy -4 - [2 - (4 -phenyl piperaz -1 -yl) ethoxy] benzyl} urea compound as well as a preparation method and application thereof in preparation of
Photocontrolled endogenous reactive oxygen species (ROS) generation
Sharma, Ajay Kumar,Singh, Harshit,Chakrapani, Harinath
supporting information, p. 5259 - 5262 (2019/05/08)
A cell-permeable small molecule for light-triggered generation of endogenous reactive oxygen species (ROS) is reported.
Sulfuryl Fluoride Mediated Conversion of Aldehydes to Nitriles
Gurjar, Jitendra,Bater, Jorick,Fokin, Valery V.
, p. 1906 - 1909 (2019/01/24)
Aliphatic, aromatic, and heteroaromatic aldehydes were readily converted to corresponding nitriles in a one-pot reaction sequence with hydroxylamine and sulfuryl fluoride. The reaction proceeds at room temperature, does not require metal catalysts and special precautions, and produces nitriles in excellent yields. It is compatible with a variety of functional groups, can be performed in aqueous and organic solvents, and is readily scalable to multigram quantities. Mild conditions and high selectivity of the reaction enabled the construction of polyfunctional probes containing nitrile, alkyne, azide, and fluorosulfate groups for further orthogonal derivatization.
Fe3O4@SiO2@Im-bisethylFc [HC2O4] as a novel recyclable heterogeneous nanocatalyst for synthesis of bis-coumarin derivatives
Teimuri-Mofrad, Reza,Tahmasebi, Shabnam,Payami, Elmira
, (2019/04/26)
Nanomagnetic bisethylferrocene-containing ionic liquid supported on silica-coated iron oxide (Fe3O4@SiO2@Im-bisethylFc [HC2O4]) as a novel catalyst was designed and synthesized. The described catalyst
Bisferrocene-containing ionic liquid supported on silica coated Fe3O4: A novel nanomagnetic catalyst for the synthesis of dihydropyrano[2,3-c]coumarin derivatives
Teimuri-Mofrad, Reza,Esmati, Somayeh,Tahmasebi, Shabnam,Gholamhosseini-Nazari, Mahdi
, p. 38 - 50 (2018/06/29)
Nanomagnetic bisferrocene-containing ionic liquid supported on silica coated Fe3O4 (Fe3O4@SiO2@imidazol-bisFc[HCO3]) as a novel heterogeneous catalyst was synthesized and the structure and
Iridium-catalysed primary alcohol oxidation and hydrogen shuttling for the depolymerisation of lignin
Lancefield, Christopher S.,Teunissen, Lucas W.,Weckhuysen, Bert M.,Bruijnincx, Pieter C. A.
, p. 3214 - 3221 (2018/07/31)
Lignin is a potentially abundant renewable resource for the production of aromatic chemicals, however its selective depolymerisation is challenging. Here, we report a new catalytic system for the depolymerisation of lignin to novel, non-phenolic monoaromatic products based on the selective β-O-4 primary alcohol dehydrogenation with a Cp?Ir-bipyridonate catalyst complex under basic conditions. We show that this system is capable of promoting the depolymerisation of model compounds and isolated lignins via a sequence of selective primary alcohol dehydrogenation, retro-aldol (Cα-Cβ) bond cleavage and in situ stabilisation of the aldehyde products by transfer (de)hydrogenation to alcohols and carboxylic acids. This method was found to give good to excellent yields of cleavage products with both etherified and free-phenolic lignin model compounds and could be applied to real lignin to generate a range of novel non-phenolic monomers including diols and di-acids. We additionally show, by using the same catalyst in a convergent, one-pot procedure, that these products can be selectively channelled towards a single di-acid product, giving much simpler product mixtures as a result.
Synthesis and evaluation of 1-(4-[18F]fluoroethyl)-7-(4′- methyl)curcumin with improved brain permeability for β-amyloid plaque imaging
Lee, Iljung,Yang, Jehoon,Lee, Jung Hee,Choe, Yearn Seong
supporting information; experimental part, p. 5765 - 5769 (2011/10/18)
Alzheimer's disease is characterized by the accumulation of β-amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) in the brain. We previously developed [18F]fluoropropylcurcumin ([18F]FP-curcumin), which demonstrated excellent bi
UV-absorbers for ophthalmic lens materials
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Page/Page column 7; 8, (2011/02/26)
UV absorbing monomers that are particularly useful in ophthalmic devices are disclosed.
