2-chloro-4-{[(3S)-1-methyl-3-pyrrolidinyl]amino}benzonitrile

Base Information

• Chemical Name: 2-chloro-4-{[(3S)-1-methyl-3-pyrrolidinyl]amino}benzonitrile
• CAS No.: 940865-73-6
• Molecular Formula: C₁₂H₁₄ClN₃
• Molecular Weight: 235.716
• Mol file: 940865-73-6.mol

Synonyms:2-chloro-4-{[(3S)-1-methyl-3-pyrrolidinyl]amino}benzonitrile

Chemical Property of 2-chloro-4-{[(3S)-1-methyl-3-pyrrolidinyl]amino}benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-4-{[(3S)-1-methyl-3-pyrrolidinyl]amino}benzonitrile

There total 2 articles about 2-chloro-4-{[(3S)-1-methyl-3-pyrrolidinyl]amino}benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

methanol (67-56-1) + 2-chloro-4-[(3S)-3-pyrrolidinylamino]benzonitrile (940865-72-5) → 2-chloro-4-{[(3S)-1-methyl-3-pyrrolidinyl]amino}benzonitrile (940865-73-6)

Guidance literature:

methanol; 2-chloro-4-[(3S)-3-pyrrolidinylamino]benzonitrile; With formaldehyd; for 1h;

With sodium tetrahydroborate;

With water;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-chloro-4-[(3S)-3-pyrrolidinylamino]benzonitrile (940865-72-5) → 2-chloro-4-{[(3S)-1-methyl-3-pyrrolidinyl]amino}benzonitrile (940865-73-6)

Guidance literature:

formaldehyd; 2-chloro-4-[(3S)-3-pyrrolidinylamino]benzonitrile; In methanol; water; at 25 ℃;

With sodium tetrahydroborate; In methanol; water; Cooling with ice;

DOI:10.1016/j.bmcl.2009.06.055

Reference yield: 45.0%

1-bromomethyl-4-fluoro-2-trifluoromethyl-benzene (206860-48-2) + 2-chloro-4-{[(3S)-1-methyl-3-pyrrolidinyl]amino}benzonitrile (940865-73-6) → 2-chloro-4-{{[4-fluoro-2-(trifluoromethyl)phenyl]methyl} [(3S)-1-methyl-3-pyrrolidinyl]amino} benzonitrile (940862-91-9)

Guidance literature:

2-chloro-4-{[(3S)-1-methyl-3-pyrrolidinyl]amino}benzonitrile; With sodium hydride; for 1h;

1-bromomethyl-4-fluoro-2-trifluoromethyl-benzene; In N,N-dimethyl-formamide; for 2h;

upstream raw materials:

methanol

2-chloro-4-[(3S)-3-pyrrolidinylamino]benzonitrile

formaldehyd

Downstream raw materials:

2-chloro-4-[[(3S)-1-methyl-3-pyrrolidiniyl](2-pyridinylmethyl)amino]benzonitrile

4-{butyl[(3S)-1-methyl-3-pyrrolidinyl]amino}-2-chlorobenzonitrile

2-chloro-4-{ethyl[(3S)-1-methyl-3-pyrrolidinyl]amino}benzonitrile

C₁₅H₂₀ClN₃