4-acetyl-α-methylbenzeneacetaldehyde

Base Information

• Chemical Name: 4-acetyl-α-methylbenzeneacetaldehyde
• CAS No.: 63476-27-7
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.215
• Mol file: 63476-27-7.mol

Synonyms:4-acetyl-α-methylbenzeneacetaldehyde

Chemical Property of 4-acetyl-α-methylbenzeneacetaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-acetyl-α-methylbenzeneacetaldehyde

There total 5 articles about 4-acetyl-α-methylbenzeneacetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-Iodoacetophenone (13329-40-3) + allyl alcohol (107-18-6) → 3-(4-acetylphenyl)-2-propenal (862893-82-1) + 4,4'-diacetylbiphenyl (787-69-9) + 4-acetyl-α-methylbenzeneacetaldehyde (63476-27-7) + 4'-(3-oxopropyl)acetophenone (150805-64-4)

Guidance literature:

With palladium diacetate; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 85 ℃; for 5h; Reagent/catalyst; Inert atmosphere;

DOI:10.1016/j.tet.2017.03.034

Reference yield:

1-Methoxy-2-[4-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-propan-2-ol → 4-acetyl-α-methylbenzeneacetaldehyde (63476-27-7)

Guidance literature:

Multi-step reaction with 2 steps

1: TsOH / benzene / Heating

2: aq. H₂SO₄ / Heating

With sulfuric acid; toluene-4-sulfonic acid; In benzene;

Reference yield:

4-Iodoacetophenone (13329-40-3) + allyl alcohol (107-18-6) → 4-acetyl-α-methylbenzeneacetaldehyde (63476-27-7) + 4'-(3-oxopropyl)acetophenone (150805-64-4)

Guidance literature:

With tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 50 ℃; for 8.5h; Schlenk technique; Inert atmosphere;

DOI:10.3998/ark.5550190.0013.321

upstream raw materials:

1-[4-((E)-2-Methoxy-1-methyl-vinyl)-phenyl]-ethanone

4-Iodoacetophenone

allyl alcohol

1-(4-vinylphenyl)ethanone

Downstream raw materials:

2-[4-(acetyl)phenyl] propanoic acid