Pyrazinecarboxylic acid, trimethyl- (9CI)

Base Information

• Chemical Name: Pyrazinecarboxylic acid, trimethyl- (9CI)
• CAS No.: 186534-01-0
• Molecular Formula: C8H10 N2 O2
• Molecular Weight: 166.18
• Mol file: 186534-01-0.mol

Synonyms:Pyrazinecarboxylicacid, trimethyl- (9CI)

Chemical Property of Pyrazinecarboxylic acid, trimethyl- (9CI)

Chemical Property:

• PSA: 63.08000
• LogP: 1.10000

Purity/Quality:

97% ^*data from raw suppliers

trimethylpyrazine-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrazinecarboxylic acid, trimethyl- (9CI)

There total 1 articles about Pyrazinecarboxylic acid, trimethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

2-Pyrazinemethanol,3,5,6-trimethyl (75907-74-3) → 3,5,6-trimethylpyrazine-2-carboxylic acid (186534-01-0)

Guidance literature:

With potassium permanganate; In water; at 20 ℃; for 0.666667h;

DOI:10.2174/157340612802084243

Reference yield: 93.5%

3,5,6-trimethylpyrazine-2-carboxylic acid (186534-01-0) + 4-aminomethylphenol (696-60-6) → N-(4-hydroxybenzyl)-3,5,6-trimethylpyrazine-2-carboxamide

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1039/c7md00003k

Reference yield: 93.2%

3,5,6-trimethylpyrazine-2-carboxylic acid (186534-01-0) + podofilox (518-28-5) → (5R,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydrofuro[30,4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl-3,5,6-trimethylpyrazine-2-carboxylate

Guidance literature:

3,5,6-trimethylpyrazine-2-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h;

podofilox; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 4h;

DOI:10.1016/j.ejmech.2018.05.052

upstream raw materials:

2-Pyrazinemethanol,3,5,6-trimethyl

Downstream raw materials:

methyl 3,5,6-trimethylpyrazine-2-carboxylate

3,5,6-trimethyl-N-(N-p-tolylcarbamimidoyl)pyrazine-2-carboxamide

N-(N-(4-methoxyphenyl)carbamimidoyl)-3,5,6-trimethylpyrazine-2-carboxamide

N-(N-(4-fluorobenzyl)carbamimidoyl)-3,5,6-trimethylpyrazine-2-carboxamide