Amino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester; hydrochloride

Base Information

Chemical Name:Amino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester; hydrochloride
CAS No.:75320-11-5
Molecular Formula:C₂₂H₁₉Cl₂N₃O₄*ClH
Molecular Weight:496.777
Hs Code.:

Synonyms:Amino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester; hydrochloride

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Chemical Property of Amino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester; hydrochloride

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Technology Process of Amino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester; hydrochloride

There total 2 articles about Amino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75320-03-5
tert-Butoxycarbonylamino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester

: 75320-11-5
Amino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2.75h;
DOI:10.1021/jm00186a030

Reference yield:

: 75319-92-5
2-(2'-hydroxyethyl)-4-acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one

: 75320-11-5
Amino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Et₃N, pivaloyl chloride / 1.) THF, 20 deg C, 2.) THF, 20 deg C

2: 6M HCl / dioxane / 2.75 h / 20 °C

With hydrogenchloride; pivaloyl chloride; triethylamine; In 1,4-dioxane;
DOI:10.1021/jm00186a030