tert-Butoxycarbonylamino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester

Base Information

• Chemical Name: tert-Butoxycarbonylamino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester
• CAS No.: 75320-03-5
• Molecular Formula: C₂₇H₂₇Cl₂N₃O₆
• Molecular Weight: 560.434

Synonyms:tert-Butoxycarbonylamino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester

Chemical Property of tert-Butoxycarbonylamino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester

Chemical Property:

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Technology Process of tert-Butoxycarbonylamino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester

There total 1 articles about tert-Butoxycarbonylamino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

BOC-glycine (4530-20-5) + 2-(2'-hydroxyethyl)-4-acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one (75319-92-5) → tert-Butoxycarbonylamino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester (75320-03-5)

Guidance literature:

With pivaloyl chloride; triethylamine; Yield given. Multistep reaction; 1.) THF, 20 deg C, 2.) THF, 20 deg C;

DOI:10.1021/jm00186a030

Reference yield:

tert-Butoxycarbonylamino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester (75320-03-5) → Amino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester; hydrochloride (75320-11-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2.75h;

DOI:10.1021/jm00186a030

upstream raw materials:

BOC-glycine

2-(2'-hydroxyethyl)-4-acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one

Downstream raw materials:

Amino-acetic acid 2-[5-acetyl-3,4-bis-(4-chloro-phenyl)-6-oxo-6H-pyridazin-1-yl]-ethyl ester; hydrochloride

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