4-Acetyl-2-(2'-hydroxyethyl)-5,6-bis(4-chlorophenyl)-2H-pyridazin-3-one

Base Information

Chemical Name:4-Acetyl-2-(2'-hydroxyethyl)-5,6-bis(4-chlorophenyl)-2H-pyridazin-3-one
CAS No.:75319-92-5
Molecular Formula:C20H16Cl2N2O3
Molecular Weight:403.265
Hs Code.:
NSC Number:351481
UNII:Y44P84U6PW
DSSTox Substance ID:DTXSID40226282
Wikidata:Q83105645
ChEMBL ID:CHEMBL286581
Mol file:75319-92-5.mol

Synonyms:4-acetyl-2-(2'-hydroxyethyl)-5,6-bis(4-chlorophenyl)-2H-pyridazin-3-one

Suppliers and Price of 4-Acetyl-2-(2'-hydroxyethyl)-5,6-bis(4-chlorophenyl)-2H-pyridazin-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-ACETYL-2-(2'-HYDROXYETHYL)-5,6-BIS(4-CHLOROPHENYL)-2H-PYRIDAZIN-3-ONE 95.00%
5MG
$ 495.97

Total 5 raw suppliers

Chemical Property of 4-Acetyl-2-(2'-hydroxyethyl)-5,6-bis(4-chlorophenyl)-2H-pyridazin-3-one

Chemical Property:

Vapor Pressure:2.15E-14mmHg at 25°C
Refractive Index:1.637
Boiling Point:582.1°C at 760 mmHg
Flash Point:305.9°C
PSA：72.19000
Density:1.37g/cm³
LogP:4.07900
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:402.0537978
Heavy Atom Count:27
Complexity:646

Purity/Quality:

99% ^*data from raw suppliers

4-ACETYL-2-(2'-HYDROXYETHYL)-5,6-BIS(4-CHLOROPHENYL)-2H-PYRIDAZIN-3-ONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1=C(C(=NN(C1=O)CCO)C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)Cl

Technology Process of 4-Acetyl-2-(2'-hydroxyethyl)-5,6-bis(4-chlorophenyl)-2H-pyridazin-3-one

There total 2 articles about 4-Acetyl-2-(2'-hydroxyethyl)-5,6-bis(4-chlorophenyl)-2H-pyridazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.1%

: 96-49-1
[1,3]-dioxolan-2-one

: 75643-31-1
4-Acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one

: 75319-92-5
2-(2'-hydroxyethyl)-4-acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 95 ℃; for 2h;
DOI:10.1002/jps.2600700419

Reference yield:

: 40036-75-7
(E)-4,4'-dichlorobenzil monohydrazone

: 75319-92-5
2-(2'-hydroxyethyl)-4-acetyl-5,6-bis(p-chlorophenyl)-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / xylene / 7 h / 110 - 136 °C

2: 99.1 percent / potassium carbonate / dimethylformamide / 2 h / 95 °C

With pyridine; potassium carbonate; In N,N-dimethyl-formamide; xylene;
DOI:10.1002/jps.2600700419