[(2R,3S)-2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-5-oxo-tetrahydro-furan-3-yl]-nitro-acetic acid ethyl ester

Base Information

• Chemical Name: [(2R,3S)-2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-5-oxo-tetrahydro-furan-3-yl]-nitro-acetic acid ethyl ester
• CAS No.: 180719-32-8
• Molecular Formula: C₁₈H₂₉NO₇
• Molecular Weight: 371.431
• Mol file: 180719-32-8.mol

Synonyms:[(2R,3S)-2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-5-oxo-tetrahydro-furan-3-yl]-nitro-acetic acid ethyl ester

Chemical Property of [(2R,3S)-2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-5-oxo-tetrahydro-furan-3-yl]-nitro-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of [(2R,3S)-2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-5-oxo-tetrahydro-furan-3-yl]-nitro-acetic acid ethyl ester

There total 1 articles about [(2R,3S)-2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-5-oxo-tetrahydro-furan-3-yl]-nitro-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

nitroacetic acid ethyl ester (626-35-7) + (5R)-(L-menthyloxy)-2(5H)-furanone (112968-75-9,122079-41-8,122079-45-2,135041-07-5,77934-87-3) → [(2R,3S)-2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-5-oxo-tetrahydro-furan-3-yl]-nitro-acetic acid ethyl ester (180719-32-8)

Guidance literature:

With sodium ethanolate; In N,N-dimethyl-formamide; for 24h; Ambient temperature;

DOI:10.1021/jo951902z

Reference yield: 96.0%

ethyl iodide (75-03-6) + [(2R,3S)-2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-5-oxo-tetrahydro-furan-3-yl]-nitro-acetic acid ethyl ester (180719-32-8) → (Z)-(+)-ethyl nitronic ester of (4S*,5R)-4-(1'-nitro-1'-carbethoxymethyl)-5-((1R)-menthyloxy)-3,4-dihydro-2(5H)-furanone

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 2h; Ambient temperature;

DOI:10.1021/jo951902z

Reference yield: 96.0%

[(2R,3S)-2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-5-oxo-tetrahydro-furan-3-yl]-nitro-acetic acid ethyl ester (180719-32-8) + methyl iodide (74-88-4) → (Z)-(+)-methyl nitronic ester of (4S*,5R)-4-(1'-nitro-1'-carbethoxymethyl)-5-((1R)-menthyloxy)-3,4-dihydro-2(5H)-furanone

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 1.5h; Ambient temperature;

DOI:10.1021/jo951902z

upstream raw materials:

nitroacetic acid ethyl ester

(5R)-(L-menthyloxy)-2(5H)-furanone