2-(2-(2-(2-(4-(methylamino)phenyl)benzofuran-5-yloxy)ethoxy)ethoxy)ethanol

Base Information

Chemical Name:2-(2-(2-(2-(4-(methylamino)phenyl)benzofuran-5-yloxy)ethoxy)ethoxy)ethanol
CAS No.:1287783-09-8
Molecular Formula:C₂₁H₂₅NO₅
Molecular Weight:371.433
Hs Code.:

Synonyms:2-(2-(2-(2-(4-(methylamino)phenyl)benzofuran-5-yloxy)ethoxy)ethoxy)ethanol

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Chemical Property of 2-(2-(2-(2-(4-(methylamino)phenyl)benzofuran-5-yloxy)ethoxy)ethoxy)ethanol

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Technology Process of 2-(2-(2-(2-(4-(methylamino)phenyl)benzofuran-5-yloxy)ethoxy)ethoxy)ethanol

There total 6 articles about 2-(2-(2-(2-(4-(methylamino)phenyl)benzofuran-5-yloxy)ethoxy)ethoxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.2%

: 2-(4-methylamino-phenyl)-benzofuran-5-ol

: 5197-62-6
2-[2-(chloroethoxy)ethoxy]ethanol

: 1287783-09-8
2-(2-(2-(2-(4-(methylamino)phenyl)benzofuran-5-yloxy)ethoxy)ethoxy)ethanol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 18h;
DOI:10.1021/jm200057u

Reference yield:

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 1287783-09-8
2-(2-(2-(2-(4-(methylamino)phenyl)benzofuran-5-yloxy)ethoxy)ethoxy)ethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / Reflux

2.1: tin(ll) chloride / ethanol / 2 h / Reflux

3.1: sodium methylate / methanol / 1 h / Reflux

3.2: 2 h / Reflux

4.1: boron tribromide / dichloromethane / 1 h / 20 °C / Cooling with ice

4.2: Cooling with ice

5.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

With sodium methylate; boron tribromide; potassium carbonate; tin(ll) chloride; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200057u

Reference yield:

: 888704-00-5
[4-(5-methoxy-benzofuran-2-yl)-phenyl]-methyl-amine

: 1287783-09-8
2-(2-(2-(2-(4-(methylamino)phenyl)benzofuran-5-yloxy)ethoxy)ethoxy)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: boron tribromide / dichloromethane / 1 h / 20 °C / Cooling with ice

1.2: Cooling with ice

2.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

With boron tribromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200057u