tert-butyl 4-(5-(2-(2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethoxy)ethoxy)benzofuran-2-yl)phenyl-N-methylcarbamate

Base Information

Chemical Name:tert-butyl 4-(5-(2-(2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethoxy)ethoxy)benzofuran-2-yl)phenyl-N-methylcarbamate
CAS No.:1287783-11-2
Molecular Formula:C₃₂H₄₇NO₇Si
Molecular Weight:585.813
Hs Code.:

Synonyms:tert-butyl 4-(5-(2-(2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethoxy)ethoxy)benzofuran-2-yl)phenyl-N-methylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 4-(5-(2-(2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethoxy)ethoxy)benzofuran-2-yl)phenyl-N-methylcarbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl 4-(5-(2-(2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethoxy)ethoxy)benzofuran-2-yl)phenyl-N-methylcarbamate

There total 8 articles about tert-butyl 4-(5-(2-(2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethoxy)ethoxy)benzofuran-2-yl)phenyl-N-methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.6%

: 24424-99-5
di-tert-butyl dicarbonate

: 1287783-10-1
4-(5-(2-(2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylbenzenamine

: 1287783-11-2
tert-butyl 4-(5-(2-(2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethoxy)ethoxy)benzofuran-2-yl)phenyl-N-methylcarbamate

Guidance literature:: In tetrahydrofuran; Reflux;
DOI:10.1021/jm200057u

Reference yield:

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 1287783-11-2
tert-butyl 4-(5-(2-(2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethoxy)ethoxy)benzofuran-2-yl)phenyl-N-methylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / Reflux

2.1: tin(ll) chloride / ethanol / 2 h / Reflux

3.1: sodium methylate / methanol / 1 h / Reflux

3.2: 2 h / Reflux

4.1: boron tribromide / dichloromethane / 1 h / 20 °C / Cooling with ice

4.2: Cooling with ice

5.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

6.1: 1H-imidazole / dichloromethane / 4 h / 20 °C

7.1: tetrahydrofuran / Reflux

With 1H-imidazole; sodium methylate; boron tribromide; potassium carbonate; tin(ll) chloride; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200057u

Reference yield:

: 888704-00-5
[4-(5-methoxy-benzofuran-2-yl)-phenyl]-methyl-amine

: 1287783-11-2
tert-butyl 4-(5-(2-(2-(2-(tert-butyldimethylsilyloxy)ethoxy)ethoxy)ethoxy)benzofuran-2-yl)phenyl-N-methylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron tribromide / dichloromethane / 1 h / 20 °C / Cooling with ice

1.2: Cooling with ice

2.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

3.1: 1H-imidazole / dichloromethane / 4 h / 20 °C

4.1: tetrahydrofuran / Reflux

With 1H-imidazole; boron tribromide; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200057u