N-trifluoroacetyl tert-leucine

Base Information

Chemical Name:N-trifluoroacetyl tert-leucine
CAS No.:666832-71-9
Molecular Formula:C₈H₁₂F₃NO₃
Molecular Weight:227.183
Hs Code.:

Synonyms:N-trifluoroacetyl tert-leucine

Suppliers and Price of N-trifluoroacetyl tert-leucine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 34 raw suppliers

Chemical Property of N-trifluoroacetyl tert-leucine

Chemical Property:

Purity/Quality:: ≥99.0% ^*data from raw suppliers

Safty Information:

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Technology Process of N-trifluoroacetyl tert-leucine

There total 1 articles about N-trifluoroacetyl tert-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20859-02-3
L-tert-Leucine

: 383-63-1
ethyl trifluoroacetate,

: 666832-71-9
N-trifluoroacetyl tert-leucine

Guidance literature:: With potassium methanolate; In methanol; at 40 ℃; for 2h;
DOI:10.1021/op010011s

Reference yield:

: 666832-71-9
N-trifluoroacetyl tert-leucine

: 74-89-5
methylamine

: N'-trifluoroacetyl-S-tert-leucine N-methylamide

Guidance literature:: N-trifluoroacetyl tert-leucine; With Vilsmeier reagent; In ethyl acetate; at -15 ℃; for 2h;

methylamine; In water; ethyl acetate;
DOI:10.1021/op010011s

Reference yield:

: 666832-71-9
N-trifluoroacetyl tert-leucine

: 2628280-40-8
(1R,2S,5S)-N-{(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; dmap; p-toluenesulfonyl chloride / tetrahydrofuran / 2 h / 20 °C

1.2: 20 °C

2.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / acetonitrile / 0.17 h / 0 °C

2.2: 19.75 h / 0 - 45 °C

2.3: 3.5 h / 25 - 50 °C

3.1: Isopropyl acetate / n-heptane / 18 - 25 °C

With dmap; Isopropyl acetate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; n-heptane; acetonitrile;