159857-63-3Relevant articles and documents
Synthesis of an immunoconjugate of camptothecin
Walker, Michael A.,Dubowchik, Gene M.,Hofstead, Sandra J.,Trail, Pamela A.,Firestone, Raymond A.
, p. 217 - 219 (2002)
The first immunoconjugate of camptothecin has been synthesized wherein the drug is attached to the tumor-recognizing antibody BR96 via a Cathepsin B cleavable linker. Endocytosis of the immunoconjugate upon binding to the tumor cell followed by enzymatic cleavage of the linker inside the endosome ensures tumor-specific release of the drug. In this way, it is hoped that the dose-limiting side effects associated with camptothecin can be eliminated while the antitumor activity is preserved.
Cobalamin conjugates for anti-tumor therapy
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Page/Page column 17, (2008/06/13)
The present invention provides a cobalamin-drug conjugate suitable for the treatment of tumor related diseases. Cobalamin is indirectly covalently bound to an anti-tumor drug via a cleavable linker and one or more optional spacers. Cobalamin is covalently
