2-(4-Aminophenyl)-4-(4-fluorophenyl)-5-(4-pyridyl)-1H-imidazole

Base Information

Chemical Name:2-(4-Aminophenyl)-4-(4-fluorophenyl)-5-(4-pyridyl)-1H-imidazole
CAS No.:152121-54-5
Molecular Formula:C₂₀H₁₅FN₄
Molecular Weight:330.364
Hs Code.:
DSSTox Substance ID:DTXSID801164453
Nikkaji Number:J1.581.533G
Pharos Ligand ID:HJKPSCY8TZ1Y
ChEMBL ID:CHEMBL17736

Synonyms:152121-54-5;CHEMBL17736;2-(4-Aminophenyl)-4-(4-fluorophenyl)-5-(4-pyridyl)-1H-imidazole;4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]aniline;SCHEMBL2648969;KVIYSVXFZOEINO-UHFFFAOYSA-N;DTXSID801164453;BDBM50104352;AKOS015994574;ES-0029;2-(4-aminophenyl)4-(4-fluorophenyl)-5-(4-pyridyl)-1H-imidazole;4-[4-(4-Fluorophenyl)-5-(4-pyridyl)-1H-imidazole-2-yl]aniline;4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]-phenylamine;4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]benzenamine

Suppliers and Price of 2-(4-Aminophenyl)-4-(4-fluorophenyl)-5-(4-pyridyl)-1H-imidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 2-(4-Aminophenyl)-4-(4-fluorophenyl)-5-(4-pyridyl)-1H-imidazole

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:330.12807466
Heavy Atom Count:25
Complexity:412

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)N

Technology Process of 2-(4-Aminophenyl)-4-(4-fluorophenyl)-5-(4-pyridyl)-1H-imidazole

There total 5 articles about 2-(4-Aminophenyl)-4-(4-fluorophenyl)-5-(4-pyridyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 152121-53-4
4-(4-fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole

: 152121-54-5
2-(4-Aminophenyl)-4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazole

Guidance literature:: palladium on activated carbon; In methanol;

Reference yield:

: 116332-54-8
4-fluoro-N-methoxy-N-methylbenzamide

: 152121-54-5
2-(4-Aminophenyl)-4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / -30 °C

1.2: tetrahydrofuran / -30 - 0 °C

2.1: Cu(OAc)2; NH₄OAc; HOAc / 4 h / 115 °C

With copper diacetate; ammonium acetate; acetic acid; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/S0960-894X(01)00498-X

Reference yield:

: 117423-41-3
4-((tert-butyldimethylsilyloxy)methyl)pyridine

: 152121-54-5
2-(4-Aminophenyl)-4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / -30 °C

1.2: tetrahydrofuran / -30 - 0 °C

2.1: Cu(OAc)2; NH₄OAc; HOAc / 4 h / 115 °C

With copper diacetate; ammonium acetate; acetic acid; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/S0960-894X(01)00498-X