C₄₆H₅₁N₄O₁₅P

Base Information

• Chemical Name: C₄₆H₅₁N₄O₁₅P
• CAS No.: 169515-32-6
• Molecular Formula: C₄₆H₅₁N₄O₁₅P
• Molecular Weight: 930.902
• Mol file: 169515-32-6.mol

Synonyms:C₄₆H₅₁N₄O₁₅P

Chemical Property of C₄₆H₅₁N₄O₁₅P

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₄₆H₅₁N₄O₁₅P

There total 3 articles about C₄₆H₅₁N₄O₁₅P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3'-O-levulinoylthymidine (78635-98-0) + 5'-O-dimethoxytritylthymidine 3'-H-phosphonate (50571-26-1) → C46H51N4O15P (169515-32-6)

Guidance literature:

With polystyrene-supported acyl chloride; In pyridine; dichloromethane; for 1h;

DOI:10.1002/ejoc.200500547

Reference yield: 84.0%

triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate (3868-27-7) + 3'-O-levulinoylthymidine (78635-98-0) → C46H51N4O15P (169515-32-6)

Guidance literature:

With pivaloyl chloride; In pyridine; for 0.133333h; Ambient temperature;

DOI:10.1080/07328319708006159

Reference yield:

3'-O-levulinoylthymidine (78635-98-0) + 5'-O-dimethoxytrityl-2'-deoxythymidine-3'-H-phosphonate (130288-81-2) → C46H51N4O15P (169515-32-6)

Guidance literature:

With pyridine; 1-Adamantanecarbonyl chloride; for 0.25h; Milling;

DOI:10.1002/chem.202001193

upstream raw materials:

triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate

3'-O-levulinoylthymidine

5'-O-dimethoxytritylthymidine 3'-H-phosphonate

5'-O-dimethoxytrityl-2'-deoxythymidine-3'-H-phosphonate

Downstream raw materials:

C₇₁H₉₅N₄O₁₆PSi

C₆₆H₈₈N₅O₁₆PSi

C₆₆H₈₉N₄O₁₄PSi

C₇₁H₉₄N₅O₁₈PSi

Refernces

• 1、 Thorpe, James D.,O'Reilly, Daniel,Fri??i?, Tomislav,Damha, Masad J.. "Mechanochemical Synthesis of Short DNA Fragments". . p. 8857 - 8861. Retrieved 2020.
• 2、 Mohe, Nikhil,Heinonen, Petri,Sanghvi, Yogesh S.,Stroemberg, Roger. "A solid supported reagent for internucleoside H-phosphonate linkage formation". . p. 897 - 899. Retrieved 2007/10/03.