N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-2-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-5-methyl-4-pyridinecarbohydrazide

Base Information

Chemical Name:N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-2-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-5-methyl-4-pyridinecarbohydrazide
CAS No.:1094345-84-2
Molecular Formula:C₂₇H₂₅Cl₂FN₄O₆
Molecular Weight:591.423
Hs Code.:

Synonyms:N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-2-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-5-methyl-4-pyridinecarbohydrazide

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Chemical Property of N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-2-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-5-methyl-4-pyridinecarbohydrazide

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Technology Process of N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-2-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-5-methyl-4-pyridinecarbohydrazide

There total 16 articles about N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-2-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-5-methyl-4-pyridinecarbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1094345-82-0
2-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-5-methyl-4-pyridinecarboxylic acid

: 1093987-89-3
2-{4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetohydrazide

: 1094345-84-2
N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-2-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-5-methyl-4-pyridinecarbohydrazide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 153034-94-7
2-Fluoro-4-iodo-5-methylpyridine

: 1094345-84-2
N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-2-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-5-methyl-4-pyridinecarbohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetra(n-butyl)ammonium hydroxide; sodium hydroxide / water; toluene / 8 h / 90 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 °C

2.2: -78 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 2 h / 20 °C

With n-butyllithium; tetra(n-butyl)ammonium hydroxide; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; hexane; water; toluene;

Reference yield:

: 473923-96-5
3-chloro-5-methoxybenzonitrile

: 1094345-84-2
N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-2-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-5-methyl-4-pyridinecarbohydrazide

Guidance literature:: Multi-step reaction with 8 steps

1.1: 2,4,6-trimethyl-pyridine; lithium iodide / 8 h / 185 °C / Inert atmosphere

1.2: Cooling with ice

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 20 °C

2.3: 20 °C / Cooling with ice

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

3.2: 4 h / 0 - 20 °C

3.3: 20 °C

4.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 - 60 °C

4.2: 0 °C

5.1: sodium dithionite; water / tetrahydrofuran / 1 h / 20 °C

6.1: tert.-butylnitrite; copper dichloride / acetonitrile / 0.25 h / 50 °C

7.1: hydrazine / ethanol / 2 h / Reflux

8.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 2 h / 20 °C

With 2,4,6-trimethyl-pyridine; tert.-butylnitrite; sodium dithionite; water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; copper dichloride; lithium iodide; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; mineral oil;