3,4-dihydro-1-phenylmethyl-2(1H)-isoquinolinecarboxylic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:3,4-dihydro-1-phenylmethyl-2(1H)-isoquinolinecarboxylic acid 1,1-dimethylethyl ester
CAS No.:140367-61-9
Molecular Formula:C₂₁H₂₅NO₂
Molecular Weight:323.435
Hs Code.:

Synonyms:3,4-dihydro-1-phenylmethyl-2(1H)-isoquinolinecarboxylic acid 1,1-dimethylethyl ester

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Chemical Property of 3,4-dihydro-1-phenylmethyl-2(1H)-isoquinolinecarboxylic acid 1,1-dimethylethyl ester

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Technology Process of 3,4-dihydro-1-phenylmethyl-2(1H)-isoquinolinecarboxylic acid 1,1-dimethylethyl ester

There total 6 articles about 3,4-dihydro-1-phenylmethyl-2(1H)-isoquinolinecarboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 100-39-0
benzyl bromide

: 138350-92-2
tert-butyl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate

: 140367-61-9
3,4-dihydro-1-phenylmethyl-2(1H)-isoquinolinecarboxylic acid 1,1-dimethylethyl ester

Guidance literature:: tert-butyl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate; With n-butyllithium; In tetrahydrofuran; hexane; at -50 ℃; for 0.0666667h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; hexane; at -50 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1002/chem.201301096

Reference yield:

: 1402830-47-0
C₁₄H₁₉NO₃

: 62673-31-8
benzyl(bromo)zinc

: 140367-61-9
3,4-dihydro-1-phenylmethyl-2(1H)-isoquinolinecarboxylic acid 1,1-dimethylethyl ester

Guidance literature:: With scandium tris(trifluoromethanesulfonate); In tetrahydrofuran; at 70 ℃; for 1h; Inert atmosphere;
DOI:10.1039/d0ob01477j

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 140367-61-9
3,4-dihydro-1-phenylmethyl-2(1H)-isoquinolinecarboxylic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / CH₂Cl₂ / 1 h / Ambient temperature

2: 1) N,N,N',N'-tetramethylethylenediamine, t-BuLi / THF, pentane 1) -78 deg C, 40 min 2) -78 deg C, 3 h

With N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; In dichloromethane;
DOI:10.1002/jhet.5570280720