ethyl 4-(3-(7-methoxy-2-oxoquinolin-1(2H)-yl)propyl)-1-(2-(phenylthio)ethyl)piperidine-4-carboxylate

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Chemical Name:ethyl 4-(3-(7-methoxy-2-oxoquinolin-1(2H)-yl)propyl)-1-(2-(phenylthio)ethyl)piperidine-4-carboxylate
CAS No.:917829-00-6
Molecular Formula:C₂₉H₃₆N₂O₄S
Molecular Weight:508.682
Hs Code.:

Synonyms:ethyl 4-(3-(7-methoxy-2-oxoquinolin-1(2H)-yl)propyl)-1-(2-(phenylthio)ethyl)piperidine-4-carboxylate

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Chemical Property of ethyl 4-(3-(7-methoxy-2-oxoquinolin-1(2H)-yl)propyl)-1-(2-(phenylthio)ethyl)piperidine-4-carboxylate

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Technology Process of ethyl 4-(3-(7-methoxy-2-oxoquinolin-1(2H)-yl)propyl)-1-(2-(phenylthio)ethyl)piperidine-4-carboxylate

There total 4 articles about ethyl 4-(3-(7-methoxy-2-oxoquinolin-1(2H)-yl)propyl)-1-(2-(phenylthio)ethyl)piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 917833-74-0
ethyl 4-(3-(7-methoxy-2-oxoquinolin-1(2H)-yl)propyl)piperidine-4-carboxylate

: 4837-01-8
1-bromo-2-phenylthioethane

: 917829-00-6
ethyl 4-(3-(7-methoxy-2-oxoquinolin-1(2H)-yl)propyl)-1-(2-(phenylthio)ethyl)piperidine-4-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 4.5h;

Reference yield:

: 917833-13-7
1-tert-butyl 4-ethyl 4-(3-(benzyloxy)propyl)piperidine-1,4-dicarboxylate

: 917829-00-6
ethyl 4-(3-(7-methoxy-2-oxoquinolin-1(2H)-yl)propyl)-1-(2-(phenylthio)ethyl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h

2.1: triethylamine / tetrahydrofuran / 1 h / 5 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 20 - 60 °C

3.2: 0.5 h / 70 - 80 °C

3.3: 2.5 h

4.1: trifluoroacetic acid / chloroform / 1 h / 0 - 20 °C

4.2: pH 12.3

5.1: potassium carbonate / N,N-dimethyl-formamide / 4.5 h / 20 - 60 °C

With hydrogen; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 917829-00-6
ethyl 4-(3-(7-methoxy-2-oxoquinolin-1(2H)-yl)propyl)-1-(2-(phenylthio)ethyl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -78 °C

1.2: 10 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h

3.1: triethylamine / tetrahydrofuran / 1 h / 5 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 20 - 60 °C

4.2: 0.5 h / 70 - 80 °C

4.3: 2.5 h

5.1: trifluoroacetic acid / chloroform / 1 h / 0 - 20 °C

5.2: pH 12.3

6.1: potassium carbonate / N,N-dimethyl-formamide / 4.5 h / 20 - 60 °C

With n-butyllithium; hydrogen; sodium hydride; potassium carbonate; triethylamine; diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; chloroform; N,N-dimethyl-formamide;