1-tert-butyl 4-ethyl 4-(3-(benzyloxy)propyl)piperidine-1,4-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 4-ethyl 4-(3-(benzyloxy)propyl)piperidine-1,4-dicarboxylate
CAS No.:917833-13-7
Molecular Formula:C₂₃H₃₅NO₅
Molecular Weight:405.535
Hs Code.:

Synonyms:1-tert-butyl 4-ethyl 4-(3-(benzyloxy)propyl)piperidine-1,4-dicarboxylate

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Chemical Property of 1-tert-butyl 4-ethyl 4-(3-(benzyloxy)propyl)piperidine-1,4-dicarboxylate

Chemical Property:

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Technology Process of 1-tert-butyl 4-ethyl 4-(3-(benzyloxy)propyl)piperidine-1,4-dicarboxylate

There total 1 articles about 1-tert-butyl 4-ethyl 4-(3-(benzyloxy)propyl)piperidine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54314-84-0
1-[(3-bromopropoxy)methyl]-benzene

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 917833-13-7
1-tert-butyl 4-ethyl 4-(3-(benzyloxy)propyl)piperidine-1,4-dicarboxylate

Guidance literature:: 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -78 ℃; for 2h;

1-[(3-bromopropoxy)methyl]-benzene; In tetrahydrofuran; at 20 ℃; for 10h;

Reference yield:

: 917833-13-7
1-tert-butyl 4-ethyl 4-(3-(benzyloxy)propyl)piperidine-1,4-dicarboxylate

: ethyl 4-(3-(7-methoxy-2-oxoquinolin-1(2H)-yl)propyl)-1-((2E)-3-phenyl-2-propen-1-yl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h

2.1: triethylamine / tetrahydrofuran / 1 h / 5 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 20 - 60 °C

3.2: 0.5 h / 70 - 80 °C

3.3: 2.5 h

4.1: trifluoroacetic acid / chloroform / 1 h / 0 - 20 °C

4.2: pH 12.3

5.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 4.5 h / 20 °C

With hydrogen; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; potassium iodide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 917833-13-7
1-tert-butyl 4-ethyl 4-(3-(benzyloxy)propyl)piperidine-1,4-dicarboxylate

: ethyl 4-(3-(7-methoxy-2-oxo-1,2-dihydroquinolin-1-yl)propyl)-1-(2-phenoxyethyl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h

2.1: triethylamine / tetrahydrofuran / 1 h / 5 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 20 - 60 °C

3.2: 0.5 h / 70 - 80 °C

3.3: 2.5 h

4.1: trifluoroacetic acid / chloroform / 1 h / 0 - 20 °C

4.2: pH 12.3

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 - 50 °C

With hydrogen; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; chloroform; N,N-dimethyl-formamide;