3-[N-(tert-Butyloxycarbonyl)-N-(3,3-difluoro-2-hydroxy-3-phenylsulfonyl-1-propyl)]amino-1-benzyloxynaphthalene

Base Information

Chemical Name:3-[N-(tert-Butyloxycarbonyl)-N-(3,3-difluoro-2-hydroxy-3-phenylsulfonyl-1-propyl)]amino-1-benzyloxynaphthalene
CAS No.:181574-71-0
Molecular Formula:C₃₁H₃₁F₂NO₆S
Molecular Weight:583.653
Hs Code.:

Synonyms:3-[N-(tert-Butyloxycarbonyl)-N-(3,3-difluoro-2-hydroxy-3-phenylsulfonyl-1-propyl)]amino-1-benzyloxynaphthalene

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Chemical Property of 3-[N-(tert-Butyloxycarbonyl)-N-(3,3-difluoro-2-hydroxy-3-phenylsulfonyl-1-propyl)]amino-1-benzyloxynaphthalene

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Technology Process of 3-[N-(tert-Butyloxycarbonyl)-N-(3,3-difluoro-2-hydroxy-3-phenylsulfonyl-1-propyl)]amino-1-benzyloxynaphthalene

There total 3 articles about 3-[N-(tert-Butyloxycarbonyl)-N-(3,3-difluoro-2-hydroxy-3-phenylsulfonyl-1-propyl)]amino-1-benzyloxynaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: α-lithio phenyl difluoromethylsulfone

: 181574-70-9
3-[N-(tert-Butyloxycarbonyl)-N-(formylmethyl)]amino-1-benzyloxynaphthalene

: 181574-71-0
3-[N-(tert-Butyloxycarbonyl)-N-(3,3-difluoro-2-hydroxy-3-phenylsulfonyl-1-propyl)]amino-1-benzyloxynaphthalene

Guidance literature:: In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃;
DOI:10.1021/ja961888n

Reference yield:

: 122745-36-2
N-(tert-butyloxycarbonyl)-4-(benzyloxy)-2-naphthylamine

: 181574-71-0
3-[N-(tert-Butyloxycarbonyl)-N-(3,3-difluoro-2-hydroxy-3-phenylsulfonyl-1-propyl)]amino-1-benzyloxynaphthalene

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / NaH / dimethylformamide / 24 h / 0 - 25 °C

2: 1.) O₃, 2.) Me₂S

3: 51 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

With dimethylsulfide; sodium hydride; ozone; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide;
DOI:10.1021/ja961888n

Reference yield:

: 181574-69-6
3-[N-(tert-Butyloxycarbonyl)-N-(3-methyl-2-buten-1-yl)]amino-1-benzyloxynaphthalene

: 181574-71-0
3-[N-(tert-Butyloxycarbonyl)-N-(3,3-difluoro-2-hydroxy-3-phenylsulfonyl-1-propyl)]amino-1-benzyloxynaphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) O₃, 2.) Me₂S

2: 51 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

With dimethylsulfide; ozone; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/ja961888n