Cyclohexanol,1,5-dimethyl-2-(1-methylethyl)-,(1S,2S,5R)-(9CI)

Base Information

• Chemical Name: Cyclohexanol,1,5-dimethyl-2-(1-methylethyl)-,(1S,2S,5R)-(9CI)
• CAS No.: 184178-98-1
• Molecular Formula: C₁₁H₂₂O
• Molecular Weight: 170.295
• Mol file: 184178-98-1.mol

Synonyms:Cyclohexanol,1,5-dimethyl-2-(1-methylethyl)-, [1S-(1a,2a,5b)]-;(1S,2S,5R)-2-Isopropyl-1,5-dimethylcyclohexanol

Chemical Property of Cyclohexanol,1,5-dimethyl-2-(1-methylethyl)-,(1S,2S,5R)-(9CI)

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexanol,1,5-dimethyl-2-(1-methylethyl)-,(1S,2S,5R)-(9CI)

There total 19 articles about Cyclohexanol,1,5-dimethyl-2-(1-methylethyl)-,(1S,2S,5R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2R,5S)-menthone (10458-14-7,14073-97-3,17627-49-5,7786-64-3) + methylmagnesium bromide (75-16-1) → (1S,2S,5R)-1,5-dimethyl-2-(1-methylethyl)cyclohexan-1-ol (38618-25-6,184178-98-1,727731-05-7,812697-61-3)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.8b03299

Reference yield: 82.0%

methyl bromide (74-83-9) + (2R,5S)-menthone (10458-14-7,14073-97-3,17627-49-5,7786-64-3) → (1R,2R,5S)-2-isopropyl-1,5-dimethylcyclohexanol (184178-98-1,727731-05-7,812697-61-3)

Guidance literature:

methyl bromide; With magnesium;

(2R,5S)-menthone; With cerium(III) chloride; In tetrahydrofuran; at 0 ℃; for 1.5h;

DOI:10.1021/jacs.7b11964

Reference yield: 69.0%

methyl magnesium iodide (917-64-6) + (2R,5S)-menthone (10458-14-7,14073-97-3,17627-49-5,7786-64-3) → (1S,2S,5R)-1,5-dimethyl-2-(1-methylethyl)cyclohexan-1-ol (38618-25-6,184178-98-1,727731-05-7,812697-61-3)

Guidance literature:

With cerium(III) chloride; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/S0957-4166(00)00087-2

upstream raw materials:

methyl magnesium iodide

(1R,4R)-(+)-isomenthone

(2R,5S)-menthone

diethyl ether