1-p-nitrobenzyl-(2-fucosyl)-lactose

Base Information

• Chemical Name: 1-p-nitrobenzyl-(2-fucosyl)-lactose
• CAS No.: 1363444-62-5
• Molecular Formula: C₂₅H₄₀N₂O₁₆
• Molecular Weight: 624.596
• Mol file: 1363444-62-5.mol

Synonyms:1-p-nitrobenzyl-(2-fucosyl)-lactose

Chemical Property of 1-p-nitrobenzyl-(2-fucosyl)-lactose

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 1-p-nitrobenzyl-(2-fucosyl)-lactose

There total 1 articles about 1-p-nitrobenzyl-(2-fucosyl)-lactose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

p-nitrobenzylamine (7409-30-5) + 2'-O-fucosyllactose (14843-73-3,109959-07-1,109959-10-6) → 1-p-nitrobenzyl-(2-fucosyl)-lactose (1363444-62-5)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In dimethyl sulfoxide; at 65 ℃; for 4h;

DOI:10.1021/ja211312u

Reference yield:

1-p-nitrobenzyl-(2-fucosyl)-lactose (1363444-62-5) + uridine diphosphate 2-deoxy-2-(2-oxopropyl)-α-D-galactopyranose → C34H54N2O21 (1363444-68-1)

Guidance literature:

With recombinant human blood group A antigen glycosyltransferase; at 4 ℃; pH=7.5; aq. buffer; Darkness; Enzymatic reaction;

DOI:10.1021/ja211312u

Reference yield:

1-p-nitrobenzyl-(2-fucosyl)-lactose (1363444-62-5) + uridine 5'-diphospho-2-azidoacetamido-2-deoxy-α-D-galactopyranose → C33H52N6O21 (1363444-66-9)

Guidance literature:

With recombinant human blood group A antigen glycosyltransferase; at 4 ℃; pH=7.5; aq. buffer; Darkness; Enzymatic reaction;

DOI:10.1021/ja211312u

upstream raw materials:

p-nitrobenzylamine

2'-O-fucosyllactose

Downstream raw materials:

C₃₄H₅₄N₂O₂₁

C₄₆H₇₃N₇O₂₄S

C₃₃H₅₂N₆O₂₁

Refernces

• 1、 Chaubard, Jean-Luc,Krishnamurthy, Chithra,Yi, Wen,Smith, David F.,Hsieh-Wilson, Linda C.. "Chemoenzymatic probes for detecting and imaging fucose-α(1-2)- galactose glycan biomarkers". supporting information; experimental part. p. 4489 - 4492. Retrieved 2012/04/23.