2'-O-fucosyllactose

Base Information

• Chemical Name: 2'-O-fucosyllactose
• CAS No.: 14843-73-3
• Molecular Formula: C₁₈H₃₂O₁₅
• Molecular Weight: 488.443
• Mol file: 14843-73-3.mol

Synonyms:

Chemical Property of 2'-O-fucosyllactose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-O-fucosyllactose

There total 1 articles about 2'-O-fucosyllactose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

guanosine 5'-diphospho-D-mannose (991-43-5,3123-67-9,5572-04-3,5750-57-2,6815-91-4,10108-97-1,20236-92-4,20406-59-1,26234-84-4,26378-86-9,41432-88-6,55331-69-6,78391-95-4) → 2'-O-fucosyllactose (14843-73-3,109959-07-1,109959-10-6)

Guidance literature:

Multi-step reaction with 3 steps

1: GDP-D-mannose 4,6-dehydratase; Tris*HCl; MgCl₂ / H₂O / 1 h / 37 °C / pH 7.5 / Enzymatic reaction

2: 78 percent / GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase-4-reductase; NADPH / aq. phosphate buffer / 1 h / 37 °C / pH 6.0 / Enzymatic reaction

3: 65 percent / GT-FucT₂; Tris*HCl; MnCl₂ / H₂O / 8 h / 37 °C / pH 7.5 / Enzymatic reaction

With GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase-4-reductase; GDP-D-mannose 4,6-dehydratase; GT-FucT₂; tris hydrochloride; NADPH; magnesium chloride; manganese(ll) chloride; In phosphate buffer; water;

DOI:10.1016/S0008-6215(01)00177-X

Reference yield: 56.0%

p-nitrobenzylamine (7409-30-5) + 2'-O-fucosyllactose (14843-73-3,109959-07-1,109959-10-6) → 1-p-nitrobenzyl-(2-fucosyl)-lactose (1363444-62-5)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In dimethyl sulfoxide; at 65 ℃; for 4h;

DOI:10.1021/ja211312u

Reference yield: 30.0%

C15H9ClF4N8O2 + 2'-O-fucosyllactose (14843-73-3,109959-07-1,109959-10-6) → C33H40F4N8O17

Guidance literature:

With 4-methyl-morpholine; In tetrahydrofuran; water;

DOI:10.1021/acs.bioconjchem.9b00432

upstream raw materials:

guanosine 5'-diphospho-D-mannose

Downstream raw materials:

1-p-nitrobenzyl-(2-fucosyl)-lactose

C₃₃H₅₂N₆O₂₁

Refernces