tert-butyl 2-methoxy-6-(3-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)-3-oxoprop-1-ynyl)phenylcarbamate

Base Information

Chemical Name:tert-butyl 2-methoxy-6-(3-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)-3-oxoprop-1-ynyl)phenylcarbamate
CAS No.:1067914-90-2
Molecular Formula:C₂₅H₂₇N₃O₆
Molecular Weight:465.506
Hs Code.:

Synonyms:tert-butyl 2-methoxy-6-(3-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)-3-oxoprop-1-ynyl)phenylcarbamate

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Chemical Property of tert-butyl 2-methoxy-6-(3-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)-3-oxoprop-1-ynyl)phenylcarbamate

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Technology Process of tert-butyl 2-methoxy-6-(3-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)-3-oxoprop-1-ynyl)phenylcarbamate

There total 10 articles about tert-butyl 2-methoxy-6-(3-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)-3-oxoprop-1-ynyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1067914-86-6
tert-butyl 2-ethynyl-6-methoxyphenylcarbamate

: 1067914-89-9
N-methoxy-7-(2-methoxyethoxy)-N-methylimidazo[1,2-a]pyridine-3-carboxamide

: 1067914-90-2
tert-butyl 2-methoxy-6-(3-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)-3-oxoprop-1-ynyl)phenylcarbamate

Guidance literature:: tert-butyl 2-ethynyl-6-methoxyphenylcarbamate; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

N-methoxy-7-(2-methoxyethoxy)-N-methylimidazo[1,2-a]pyridine-3-carboxamide; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

With water; ammonium chloride; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 1067914-32-2
2-chloro-4-(2-methoxyethoxy)pyridine

: 1067914-90-2
tert-butyl 2-methoxy-6-(3-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)-3-oxoprop-1-ynyl)phenylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tetrahydrofuran / 18.16 h / 60 °C

1.2: 20 °C

1.3: pH 11

2.1: ethanol / Heating / reflux

3.1: lithium hydroxide; ethanol / tetrahydrofuran

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

5.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

5.2: 2 h / -78 - 20 °C

With lithium hydroxide; n-butyllithium; ethanol; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 154150-18-2
tert-butyl 2-methoxyphenylcarbamate

: 1067914-90-2
tert-butyl 2-methoxy-6-(3-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)-3-oxoprop-1-ynyl)phenylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tert.-butyl lithium / diethyl ether / 3 h / -20 °C

1.2: -100 - 20 °C

2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran

3.1: methanol; potassium carbonate / 0.5 h

4.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

4.2: 2 h / -78 - 20 °C

With methanol; n-butyllithium; tert.-butyl lithium; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; diethyl ether;