[(4R,5R)-5-(4-Methoxy-benzyloxymethyl)-2,2,4-trimethyl-[1,3]dioxolan-4-ylethynyl]-trimethyl-silane

Base Information

Chemical Name:[(4R,5R)-5-(4-Methoxy-benzyloxymethyl)-2,2,4-trimethyl-[1,3]dioxolan-4-ylethynyl]-trimethyl-silane
CAS No.:202814-85-5
Molecular Formula:C₂₀H₃₀O₄Si
Molecular Weight:362.541
Hs Code.:

Synonyms:[(4R,5R)-5-(4-Methoxy-benzyloxymethyl)-2,2,4-trimethyl-[1,3]dioxolan-4-ylethynyl]-trimethyl-silane

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Chemical Property of [(4R,5R)-5-(4-Methoxy-benzyloxymethyl)-2,2,4-trimethyl-[1,3]dioxolan-4-ylethynyl]-trimethyl-silane

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Technology Process of [(4R,5R)-5-(4-Methoxy-benzyloxymethyl)-2,2,4-trimethyl-[1,3]dioxolan-4-ylethynyl]-trimethyl-silane

There total 5 articles about [(4R,5R)-5-(4-Methoxy-benzyloxymethyl)-2,2,4-trimethyl-[1,3]dioxolan-4-ylethynyl]-trimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 75-77-4
chloro-trimethyl-silane

: 198820-49-4
(4R,5R)-4-ethinyl-5-(4-methoxybenzyloxymethyl)-2,2,4-trimethyl-1,3-dioxolane

: 202814-85-5
[(4R,5R)-5-(4-Methoxy-benzyloxymethyl)-2,2,4-trimethyl-[1,3]dioxolan-4-ylethynyl]-trimethyl-silane

Guidance literature:: With lithium hexamethyldisilazane;
DOI:10.1002/anie.199727941

Reference yield:

: 174416-86-5
1-methoxy-4-({[(E)-3-methylpent-2-en-4-yn-1-yl]oxy}methyl)benzene

: 202814-85-5
[(4R,5R)-5-(4-Methoxy-benzyloxymethyl)-2,2,4-trimethyl-[1,3]dioxolan-4-ylethynyl]-trimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: AD-mix-β, CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 48 h / 0 °C

2: 95 percent / CuSO₄, dl-camphorsulfonic acid / acetone / 3 h / 0 °C

3: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 10 min, 2.) THF, 0 deg C, 20 min

With methanesulfonamide; AD-mix-β; camphor-10-sulfonic acid; copper(II) sulfate; lithium hexamethyldisilazane; In water; acetone; tert-butyl alcohol;
DOI:10.1021/ja980801q

Reference yield:

: 174416-87-6
(2R,3R)-1-(4-methoxybenzyloxy)-3-methylpent-4-yne-2,3-diol

: 202814-85-5
[(4R,5R)-5-(4-Methoxy-benzyloxymethyl)-2,2,4-trimethyl-[1,3]dioxolan-4-ylethynyl]-trimethyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / CuSO₄, dl-camphorsulfonic acid / acetone / 3 h / 0 °C

2: 1.) lithium hexamethyldisilazide / 1.) THF, -78 deg C, 10 min, 2.) THF, 0 deg C, 20 min

With camphor-10-sulfonic acid; copper(II) sulfate; lithium hexamethyldisilazane; In acetone;
DOI:10.1021/ja980801q