4-(3-triisopropylsilanyloxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(3-triisopropylsilanyloxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester
CAS No.:862261-23-2
Molecular Formula:C₂₄H₄₂N₂O₃Si
Molecular Weight:434.695
Hs Code.:

4-(3-triisopropylsilanyloxy-phenyl)-piperazine-1-carboxylic acid <i>tert</i>-butyl ester

Synonyms:4-(3-triisopropylsilanyloxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(3-triisopropylsilanyloxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of 4-(3-triisopropylsilanyloxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

There total 1 articles about 4-(3-triisopropylsilanyloxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 571202-87-4
3-bromophenyl triisopropylsilyl ether

: 862261-23-2
4-(3-triisopropylsilanyloxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: With palladium diacetate; tri-tert-butyl phosphine; sodium t-butanolate; In toluene;
DOI:10.1016/j.bmcl.2005.05.043

Reference yield: 100.0%

: 862261-23-2
4-(3-triisopropylsilanyloxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

: 198627-86-0
1,1-dimethylethyl 4-(3-hydroxyphenyl)-1-piperazinecarboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2005.05.043

Reference yield:

: 862261-23-2
4-(3-triisopropylsilanyloxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

: 2-furan-2-yl-7-{3-[4-(2-morpholin-4-yl-ethyl)-piperazin-1-yl]-phenyl}-[1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran

2.1: 80 percent / Et₃N / CH₂Cl₂

3.1: 82 percent / PdCl₂ (dppf); dppf; KOAc / dioxane

4.1: 70 percent / Pd(PPh₃); aq. K₂CO₃ / acetonitrile

5.1: butan-1-ol

5.2: N,O-bis(trimethylsilyl)acetamide (BSA)

6.1: 73 percent / HCl / dioxane

With hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; Pd(PPh₃); tetrabutyl ammonium fluoride; potassium acetate; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile; butan-1-ol;
DOI:10.1016/j.bmcl.2005.05.043