4-chloro-N-(2,4-dimethylphenyl)benzamide

Base Information

• Chemical Name: 4-chloro-N-(2,4-dimethylphenyl)benzamide
• CAS No.: 127292-01-7
• Molecular Formula: C₁₅H₁₄ClNO
• Molecular Weight: 259.735
• European Community (EC) Number: 666-717-1
• NSC Number: 164399
• Mol file: 127292-01-7.mol

Synonyms:4-chloro-N-(2,4-dimethylphenyl)benzamide;127292-01-7;4-Chloro-N-(2,4-diMethylphenyl)benzaMide, 97per cent;NSC164399;Cambridge id 5344988;STK031018;AKOS002162578;NSC-164399;4-CHLORO-2',4'-BENZOXYLIDIDE;CS-0360374;AB00081683-01

Chemical Property of 4-chloro-N-(2,4-dimethylphenyl)benzamide

Chemical Property:

• XLogP3: 3.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 259.0763918
• Heavy Atom Count: 18
• Complexity: 286

Purity/Quality:

99% ^*data from raw suppliers

4-CHLORO-2',4'-BENZOXYLIDIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)NC(=O)C2=CC=C(C=C2)Cl)C

Technology Process of 4-chloro-N-(2,4-dimethylphenyl)benzamide

There total 3 articles about 4-chloro-N-(2,4-dimethylphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

p-chlorobenzenediazonium tetrafluoroborate (673-41-6) + 2,4-dimethylphenylisocyanide (3100-93-4) → 4-chloro-N-(2,4-dimethylphenyl)benzamide (127292-01-7)

Guidance literature:

With water; caesium carbonate; In acetone; at 0 ℃; for 0.333333h; Schlenk technique; Inert atmosphere;

DOI:10.1021/ol4017244

Reference yield:

4-chloro-aniline (106-47-8) → 4-chloro-N-(2,4-dimethylphenyl)benzamide (127292-01-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrofluoroboric acid; sodium nitrite / water / 0.58 h / 0 °C

2: caesium carbonate; water / acetone / 0.33 h / 0 °C / Schlenk technique; Inert atmosphere

With hydrofluoroboric acid; water; caesium carbonate; sodium nitrite; In water; acetone;

DOI:10.1021/ol4017244

Reference yield:

4-chloro-benzoyl chloride (122-01-0) + 2,4-Xylidine (95-68-1) → 4-chloro-N-(2,4-dimethylphenyl)benzamide (127292-01-7)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; for 12h; Heating;

DOI:10.1002/jps.2600790308

upstream raw materials:

4-chloro-benzoyl chloride

2,4-Xylidine

p-chlorobenzenediazonium tetrafluoroborate

2,4-dimethylphenylisocyanide