3-{5-[(4-formyloxy)butanoylamino]-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoic acid

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Chemical Name:3-{5-[(4-formyloxy)butanoylamino]-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoic acid
CAS No.:197708-48-8
Molecular Formula:C₂₇H₃₃NO₇
Molecular Weight:483.562
Hs Code.:

Synonyms:3-{5-[(4-formyloxy)butanoylamino]-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoic acid

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Chemical Property of 3-{5-[(4-formyloxy)butanoylamino]-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoic acid

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Technology Process of 3-{5-[(4-formyloxy)butanoylamino]-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoic acid

There total 15 articles about 3-{5-[(4-formyloxy)butanoylamino]-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 64-18-6
formic acid

: 197708-46-6
tert-butyl-3-{5-(4-hydroxybutanoylamino)-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoate

: 197708-48-8
3-{5-[(4-formyloxy)butanoylamino]-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoic acid

Guidance literature:: at 25 ℃; for 0.5h;
DOI:10.1016/S0968-0896(97)00089-8

Reference yield:

: 502-44-3,24980-41-4,80137-66-2
hexahydro-2H-oxepin-2-one

: 197708-48-8
3-{5-[(4-formyloxy)butanoylamino]-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoic acid

Guidance literature:: Multi-step reaction with 11 steps

1: conc. sulfuric acid / 1 h / Heating

2: AlCl₃ / 1,2-dichloro-ethane / 2.5 h / 15 °C

3: 5N aq. NaOH / methanol / 1 h / 25 °C

4: NaBH₄ / methanol / 1 h / 25 - 65 °C

5: 73 percent / KCl / dimethylsulfoxide / 4 h / 170 °C

6: 92 percent / triethylamine / CH₂Cl₂ / 1 h

7: 1.) NaH / 1.) DMF, a) from 0 deg C - 25 deg C, b) 25 deg C, 30 min, 2.) DMF, 60 deg C, 2 h

8: aq. NaOH / ethanol / 1 h / Heating

9: Et₃N / tetrahydrofuran / 0.08 h / -10 °C

10: NaBH₄ / tetrahydrofuran; methanol / 0.25 h / 25 °C

11: 100 percent / 0.5 h / 25 °C

With sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; sulfuric acid; potassium chloride; sodium hydride; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1016/S0968-0896(97)00089-8

Reference yield:

: 128577-60-6
(5E)-6-(4-Methoxyphenyl)-5-hexen-1-ol

: 197708-48-8
3-{5-[(4-formyloxy)butanoylamino]-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / triethylamine / CH₂Cl₂ / 1 h

2: 1.) NaH / 1.) DMF, a) from 0 deg C - 25 deg C, b) 25 deg C, 30 min, 2.) DMF, 60 deg C, 2 h

3: aq. NaOH / ethanol / 1 h / Heating

4: Et₃N / tetrahydrofuran / 0.08 h / -10 °C

5: NaBH₄ / tetrahydrofuran; methanol / 0.25 h / 25 °C

6: 100 percent / 0.5 h / 25 °C

With sodium hydroxide; sodium tetrahydroborate; sodium hydride; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/S0968-0896(97)00089-8