Technology Process of 20-amino-3,6,9,12,15,18-hexaoxaeicosanoic acid tert-butyl ester
There total 16 articles about 20-amino-3,6,9,12,15,18-hexaoxaeicosanoic acid tert-butyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl 20-azido-3,6,9,12,15,18-hexaoxaeicosanoate;
With
triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
With
water;
In
tetrahydrofuran;
Further stages.;
DOI:10.1021/jo0012290
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 49 percent / Ag2O / CH2Cl2 / 48 h / 20 °C
2.1: 98 percent / NaN3 / dimethylformamide / 2.5 h / 110 °C
3.1: NaH / tetrahydrofuran / 1.33 h / 0 - 20 °C
3.2: 87 percent / tetrahydrofuran / 15 h / Heating
4.1: PPh3 / tetrahydrofuran / 12 h / 20 °C
4.2: 80 percent / H2O / tetrahydrofuran / 10 h
With
sodium azide; sodium hydride; triphenylphosphine; silver(l) oxide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050893b
- Guidance literature:
-
Multi-step reaction with 2 steps
1: NaN3 / toluene; dimethylformamide
2: 10.8 g / H2 / 5percent Pd/C / ethanol; CHCl3
With
sodium azide; hydrogen;
5percent Pd/C;
In
ethanol; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1002/chem.200204304
