7-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylheptanoic acid methyl ester

Base Information

Chemical Name:7-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylheptanoic acid methyl ester
CAS No.:868835-97-6
Molecular Formula:C₂₇H₄₅N₃O₅
Molecular Weight:491.671
Hs Code.:

Synonyms:7-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylheptanoic acid methyl ester

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Chemical Property of 7-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylheptanoic acid methyl ester

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Technology Process of 7-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylheptanoic acid methyl ester

There total 4 articles about 7-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylheptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.5%

: 868835-94-3
1-N-{4-[(N,N-dimethyl)amino]benzyl}-1-N-[(tert-butyloxy)carbonyl]-4-aminobutylamine

: 41624-92-4
methyl 8-chloro-8-oxooctanoate

: 868835-97-6
7-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylheptanoic acid methyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jm0505009

Reference yield: 76.5%

: 868835-97-6
7-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylheptanoic acid methyl ester

Guidance literature:

Reference yield:

: 868835-87-4
N-{4-[(N,N-dimethylamino)benzyl]butyl}phthalimide

: 868835-97-6
7-{4-[N-(tert-butyloxy)carbonyl]-4-[N,N-(dimethylamino)benzyl]amino}butylcarbamoylheptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaHCO₃; NaCl / CH₂Cl₂ / 12 h / Heating

2: 88.3 percent / hydrazine / methanol / 12 h / Heating

3: 76.5 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

With sodium hydrogencarbonate; triethylamine; sodium chloride; hydrazine; In methanol; dichloromethane;
DOI:10.1021/jm0505009