1-(2,2-Bis-benzyloxymethyl-cyclopropyl)-3-((E)-3-ethoxy-acryloyl)-urea

Base Information

• Chemical Name: 1-(2,2-Bis-benzyloxymethyl-cyclopropyl)-3-((E)-3-ethoxy-acryloyl)-urea
• CAS No.: 135345-90-3
• Molecular Formula: C₂₅H₃₀N₂O₅
• Molecular Weight: 438.524
• Mol file: 135345-90-3.mol

Synonyms:1-(2,2-Bis-benzyloxymethyl-cyclopropyl)-3-((E)-3-ethoxy-acryloyl)-urea

Chemical Property of 1-(2,2-Bis-benzyloxymethyl-cyclopropyl)-3-((E)-3-ethoxy-acryloyl)-urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,2-Bis-benzyloxymethyl-cyclopropyl)-3-((E)-3-ethoxy-acryloyl)-urea

There total 7 articles about 1-(2,2-Bis-benzyloxymethyl-cyclopropyl)-3-((E)-3-ethoxy-acryloyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

3-ethoxyacryloyl chloride (6191-99-7) + N-<2,2-bis(benzyloxymethyl)cyclopropyl>urea (135345-89-0) → 1-(2,2-Bis-benzyloxymethyl-cyclopropyl)-3-((E)-3-ethoxy-acryloyl)-urea (135345-90-3)

Guidance literature:

With pyridine; Ambient temperature;

DOI:10.1016/S0040-4039(00)71258-5

Reference yield:

2-methylenepropane-1,3-bisbenzyl ether (27441-79-8) → 1-(2,2-Bis-benzyloxymethyl-cyclopropyl)-3-((E)-3-ethoxy-acryloyl)-urea (135345-90-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 56.2 percent / cupric sulfate / 0.5 h / 90 °C

2: 84.7 percent / KOH / methanol / Ambient temperature

3: 1.) ClCO₂Et, Et₃N, 2.) NaN₃ / 1.) acetone, 0 deg C, 1 h, 2.) H₂O, room temperature, 1 h

4: 12.8 g / toluene / 1 h / 90 - 100 °C

5: NH₃ / diethyl ether

6: 1.04 g / pyridine / CH₂Cl₂ / 16 h / Ambient temperature

With pyridine; potassium hydroxide; sodium azide; ammonia; chloroformic acid ethyl ester; copper(II) sulfate; triethylamine; In methanol; diethyl ether; dichloromethane; toluene;

DOI:10.1039/P19920002519

Reference yield:

C20H21NO3 (135345-85-6) → 1-(2,2-Bis-benzyloxymethyl-cyclopropyl)-3-((E)-3-ethoxy-acryloyl)-urea (135345-90-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₃ / diethyl ether

2: 1.04 g / pyridine / CH₂Cl₂ / 16 h / Ambient temperature

With pyridine; ammonia; In diethyl ether; dichloromethane;

DOI:10.1039/P19920002519

upstream raw materials:

3-ethoxyacryloyl chloride

N-<2,2-bis(benzyloxymethyl)cyclopropyl>urea

2-methylenepropane-1,3-bisbenzyl ether

C₂₀H₂₁NO₃

Downstream raw materials:

1-<2,2-bis(benzyloxymethyl)cyclopropyl>uracil

1-<2,2-bis(toluoyloxymethyl)cyclopropyl>-5-iodo-3-toluoyluracil