1188366-14-4

Upstream product

• 477584-90-0 methyl 2-(((benzyloxy)carbonyl)amino)-2-(dihydro-2H-pyran-4(3H)-ylidene)acetate 
• 477585-43-6 methyl 2-amino-2-(tetrahydro-2H-pyran-4-yl)acetate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 

Downstream Products

• 182287-49-6 2-((tert-butoxy)carbonyl)amino-2-(tetrahydro-2H-pyran-4-yl)acetic acid 

Relevant academic research and scientific papers

AMIDE COMPOUND

The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.

SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS

The present invention relates to a series of substituted compounds having the general formula (I), including their ste reoisomers and/or their pharmaceutically acceptable salts, wherein R1, R2, R3. R4, R5, and R6 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (κ) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.