methyl 2-(6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)acetate

Base Information

• Chemical Name: methyl 2-(6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)acetate
• CAS No.: 1544664-07-4
• Molecular Formula: C₂₀H₂₁F₃O₃
• Molecular Weight: 366.38
• Mol file: 1544664-07-4.mol

Synonyms:methyl 2-(6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)acetate

Chemical Property of methyl 2-(6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)acetate

There total 3 articles about methyl 2-(6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methanol (67-56-1) + C19H19F3O3 (1544665-69-1) → methyl 2-(6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)acetate (1544664-07-4)

Guidance literature:

With sulfuric acid; Reflux;

Reference yield:

methyl 2-(6-hydroxynaphthalen-2-yl)acetate (91903-08-1) → methyl 2-(6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)acetate (1544664-07-4)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / 2-methyl-propan-1-ol / 16 h / Reflux

2: sulfuric acid / Reflux

With sulfuric acid; caesium carbonate; In 2-methyl-propan-1-ol;

Reference yield:

6-Hydroxy-2-naphthyl acetic acid (10441-46-0) → methyl 2-(6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene-2-yl)acetate (1544664-07-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 16 h / Reflux

2: caesium carbonate / 2-methyl-propan-1-ol / 16 h / Reflux

3: sulfuric acid / Reflux

With sulfuric acid; caesium carbonate; In 2-methyl-propan-1-ol;

upstream raw materials:

methanol

C₁₉H₁₉F₃O₃

methyl 2-(6-hydroxynaphthalen-2-yl)acetate

6-Hydroxy-2-naphthyl acetic acid

Downstream raw materials:

methyl 2-(5-iodo-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalen-2-yl)acetate