(S)-tert-butyl 1-(4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethylcarbamate

Base Information

• Chemical Name: (S)-tert-butyl 1-(4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethylcarbamate
• CAS No.: 1312716-45-2
• Molecular Formula: C₂₁H₂₃N₃O₃
• Molecular Weight: 365.432
• Mol file: 1312716-45-2.mol

Synonyms:(S)-tert-butyl 1-(4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethylcarbamate

Chemical Property of (S)-tert-butyl 1-(4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-tert-butyl 1-(4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethylcarbamate

There total 8 articles about (S)-tert-butyl 1-(4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(S)-tert-butyl 1-(2-carbamoylphenylamino)-1-oxo-3-phenylpropan-2-ylcarbamate (1312716-40-7) → (S)-tert-butyl 1-(4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethylcarbamate (1312716-45-2)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 0 - 20 ℃; for 0.583333h;

DOI:10.1016/j.tetasy.2011.01.009

Reference yield: 62.0%

C15H22N2O3 (1428732-35-7) + anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → (S)-tert-butyl 1-(4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethylcarbamate (1312716-45-2)

Guidance literature:

In methanol; Reflux;

DOI:10.1016/j.bmcl.2013.01.103

Reference yield: 45.0%

(S)-tert-butyl 1-(4-chloroquinazolin-2-yl)-2-phenylethylcarbamate (1312716-49-6) → (S)-tert-butyl 2-phenyl-1-(quinazolin-2-yl)ethylcarbamate (1312716-57-6) + (S)-tert-butyl 1-(4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethylcarbamate (1312716-45-2) + tert-butyl (1S,1'S)-1,1'-(4,4'-biquinazoline-2,2'-diyl)bis(2-phenylethane-1,1-diyl)dicarbamate (1312716-53-2)

Guidance literature:

(S)-tert-butyl 1-(4-chloroquinazolin-2-yl)-2-phenylethylcarbamate; With nickel(II) chloride hexahydrate; tetra-(n-butyl)ammonium iodide; triphenylphosphine; zinc; In tetrahydrofuran; at 70 ℃; for 12h; Inert atmosphere;

With ammonia; water; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.tetasy.2011.01.009

upstream raw materials:

(S)-tert-butyl 1-(2-carbamoylphenylamino)-1-oxo-3-phenylpropan-2-ylcarbamate

(S)-tert-butyl 1-(4-chloroquinazolin-2-yl)-2-phenylethylcarbamate

L-phenylalanine

di-tert-butyl dicarbonate

Downstream raw materials:

(S)-tert-butyl 1-(4-chloroquinazolin-2-yl)-2-phenylethylcarbamate

(S)-tert-butyl 2-phenyl-1-(quinazolin-2-yl)ethylcarbamate

tert-butyl (1S,1'S)-1,1'-(4,4'-biquinazoline-2,2'-diyl)bis(2-phenylethane-1,1-diyl)dicarbamate

(1S,1'S)-1,1'-(4,4'-biquinazoline-2,2'-diyl)bis(2-phenylethanamine)