(S)-tert-butyl 1-(4-chloroquinazolin-2-yl)-2-phenylethylcarbamate

Base Information

• Chemical Name: (S)-tert-butyl 1-(4-chloroquinazolin-2-yl)-2-phenylethylcarbamate
• CAS No.: 1312716-49-6
• Molecular Formula: C₂₁H₂₂ClN₃O₂
• Molecular Weight: 383.878
• Mol file: 1312716-49-6.mol

Synonyms:(S)-tert-butyl 1-(4-chloroquinazolin-2-yl)-2-phenylethylcarbamate

Chemical Property of (S)-tert-butyl 1-(4-chloroquinazolin-2-yl)-2-phenylethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-tert-butyl 1-(4-chloroquinazolin-2-yl)-2-phenylethylcarbamate

There total 6 articles about (S)-tert-butyl 1-(4-chloroquinazolin-2-yl)-2-phenylethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(S)-tert-butyl 1-(4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethylcarbamate (1312716-45-2) → (S)-tert-butyl 1-(4-chloroquinazolin-2-yl)-2-phenylethylcarbamate (1312716-49-6)

Guidance literature:

With N,N-diethylaniline; trichlorophosphate; In benzene; at 0 ℃; for 0.5h; Reflux; Inert atmosphere;

DOI:10.1016/j.tetasy.2011.01.009

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (S)-tert-butyl 1-(4-chloroquinazolin-2-yl)-2-phenylethylcarbamate (1312716-49-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium carbonate / tetrahydrofuran; water / 12 h / 0 - 20 °C

1.2: pH 2

2.1: triethylamine / tetrahydrofuran / 0.67 h / 0 °C / Inert atmosphere

3.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4.1: sodium hydroxide / ethanol; water / 0.58 h / 0 - 20 °C

5.1: N,N-diethylaniline; trichlorophosphate / benzene / 0.5 h / 0 °C / Reflux; Inert atmosphere

With sodium carbonate; triethylamine; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; water; benzene;

DOI:10.1016/j.tetasy.2011.01.009

Reference yield:

(S)-tert-butyl 1-(2-carbamoylphenylamino)-1-oxo-3-phenylpropan-2-ylcarbamate (1312716-40-7) → (S)-tert-butyl 1-(4-chloroquinazolin-2-yl)-2-phenylethylcarbamate (1312716-49-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 0.58 h / 0 - 20 °C

2: N,N-diethylaniline; trichlorophosphate / benzene / 0.5 h / 0 °C / Reflux; Inert atmosphere

With N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In ethanol; water; benzene;

DOI:10.1016/j.tetasy.2011.01.009

upstream raw materials:

(S)-tert-butyl 1-(2-carbamoylphenylamino)-1-oxo-3-phenylpropan-2-ylcarbamate

(S)-tert-butyl 1-(4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethylcarbamate

L-phenylalanine

di-tert-butyl dicarbonate

Downstream raw materials:

(S)-tert-butyl 2-phenyl-1-(quinazolin-2-yl)ethylcarbamate

(S)-tert-butyl 1-(4-oxo-3,4-dihydroquinazolin-2-yl)-2-phenylethylcarbamate

tert-butyl (1S,1'S)-1,1'-(4,4'-biquinazoline-2,2'-diyl)bis(2-phenylethane-1,1-diyl)dicarbamate

(1S,1'S)-1,1'-(4,4'-biquinazoline-2,2'-diyl)bis(2-phenylethanamine)