(R)-N-(4-(4-amino-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethyl amino)pyrrolidine-1-carboxamide

Base Information

Chemical Name:(R)-N-(4-(4-amino-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethyl amino)pyrrolidine-1-carboxamide
CAS No.:1337932-00-9
Molecular Formula:C₁₈H₂₁Cl₂N₅O₂
Molecular Weight:410.303
Hs Code.:

Synonyms:(R)-N-(4-(4-amino-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethyl amino)pyrrolidine-1-carboxamide

Suppliers and Price of (R)-N-(4-(4-amino-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethyl amino)pyrrolidine-1-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-N-(4-(4-amino-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethyl amino)pyrrolidine-1-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-N-(4-(4-amino-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethyl amino)pyrrolidine-1-carboxamide

There total 4 articles about (R)-N-(4-(4-amino-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethyl amino)pyrrolidine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1337931-99-3
(R)-N-(4-(2,3-dichloro-4-nitrophenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide

: 1337932-00-9
(R)-N-(4-(4-amino-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethyl amino)pyrrolidine-1-carboxamide

Guidance literature:: (R)-N-(4-(2,3-dichloro-4-nitrophenoxy)pyridin-2-yl)-3-(dimethylamino)pyrrolidine-1-carboxamide; With hydrogen; acetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; at 40 ℃; Thales H-cube;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: 33631-05-9
2-amino-4-hydroxypyridine

: 1337932-00-9
(R)-N-(4-(4-amino-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethyl amino)pyrrolidine-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 20 °C

1.2: 16 h / 20 °C

2.1: triethylamine / dichloromethane / 0.17 h / 0 °C

2.2: 1.5 h / 0 - 20 °C

3.1: hydrogen; acetic acid / palladium 10% on activated carbon / dichloromethane; methanol / 40 °C / Thales H-cube

With hydrogen; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane; acetonitrile;

Reference yield:

: 1337931-94-8
4-(2,3-dichloro-4-nitrophenoxy)pyridin-2-amine

: 1337932-00-9
(R)-N-(4-(4-amino-2,3-dichlorophenoxy)pyridin-2-yl)-3-(dimethyl amino)pyrrolidine-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.17 h / 0 °C

1.2: 1.5 h / 0 - 20 °C

2.1: hydrogen; acetic acid / palladium 10% on activated carbon / dichloromethane; methanol / 40 °C / Thales H-cube

With hydrogen; acetic acid; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane;