5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methylbenzoic acid hydrochloride

Base Information

Chemical Name:5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methylbenzoic acid hydrochloride
CAS No.:1448428-03-2
Molecular Formula:C₁₄H₁₃FN₂O₂*ClH
Molecular Weight:296.729
Hs Code.:

Synonyms:5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methylbenzoic acid hydrochloride

Suppliers and Price of 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methylbenzoic acid hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methylbenzoic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methylbenzoic acid hydrochloride

There total 15 articles about 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methylbenzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1448428-02-1
5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methylbenzonitrile

: 1448428-03-2
5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methylbenzoic acid hydrochloride

Guidance literature:: With hydrogenchloride; water; at 100 ℃; for 4.5h; Reflux;

Reference yield:

: 1448508-47-1
5-(4-cyclopropyl-1H-imidazole-1-yl)-2-fluoro-4-methylbenzoic acid

: 1448428-03-2
5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methylbenzoic acid hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; tert-butyl methyl ether; at 15 - 25 ℃;

Reference yield:

: 627871-16-3
5-bromo-4-fluoro-2-methylaniline

: 1448428-03-2
5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methylbenzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-methyl-pyrrolidin-2-one / 3 h / 180 °C

2.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

2.2: 3 h / 60 °C / Inert atmosphere

3.1: acetic acid / 4 h / 110 °C

4.1: dihydrogen peroxide; water / acetic acid / 1 h / 45 - 55 °C / Inert atmosphere

5.1: hydrogenchloride; water / 4.5 h / 100 °C / Reflux

With hydrogenchloride; water; dihydrogen peroxide; potassium carbonate; acetic acid; potassium iodide; In 1-methyl-pyrrolidin-2-one; acetic acid; N,N-dimethyl-formamide;