(2S)-N-(2-(4,5-dimethoxy-2-methylbenzylamino)pent-4-enoyl)-(1S,2R)-bornane-10,2-sultam

Base Information

Chemical Name:(2S)-N-(2-(4,5-dimethoxy-2-methylbenzylamino)pent-4-enoyl)-(1S,2R)-bornane-10,2-sultam
CAS No.:1363553-58-5
Molecular Formula:C₂₅H₃₆N₂O₅S
Molecular Weight:476.637
Hs Code.:

Synonyms:(2S)-N-(2-(4,5-dimethoxy-2-methylbenzylamino)pent-4-enoyl)-(1S,2R)-bornane-10,2-sultam

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Chemical Property of (2S)-N-(2-(4,5-dimethoxy-2-methylbenzylamino)pent-4-enoyl)-(1S,2R)-bornane-10,2-sultam

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Technology Process of (2S)-N-(2-(4,5-dimethoxy-2-methylbenzylamino)pent-4-enoyl)-(1S,2R)-bornane-10,2-sultam

There total 5 articles about (2S)-N-(2-(4,5-dimethoxy-2-methylbenzylamino)pent-4-enoyl)-(1S,2R)-bornane-10,2-sultam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1363553-57-4
(2S)-N-(2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)pent-4-enoyl)-(1S,2R)-bornane-10,2-sultam

: 1363553-58-5
(2S)-N-(2-(4,5-dimethoxy-2-methylbenzylamino)pent-4-enoyl)-(1S,2R)-bornane-10,2-sultam

Guidance literature:: With potassium dihydrogenphosphate; zinc; In tetrahydrofuran; water; at 20 ℃; for 7h; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.01.013

Reference yield:

: 1363553-59-6
2-allyl-5,6-dimethoxyisoindoline

: 1363553-58-5
(2S)-N-(2-(4,5-dimethoxy-2-methylbenzylamino)pent-4-enoyl)-(1S,2R)-bornane-10,2-sultam

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 120 h / 20 °C / Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran / 17 h / -40 °C / Inert atmosphere

3: 1,2-dichloro-ethane / 69 h / Reflux; Inert atmosphere

4: potassium dihydrogenphosphate; zinc / tetrahydrofuran; water / 7 h / 20 °C / Inert atmosphere

With potassium dihydrogenphosphate; potassium tert-butylate; zinc; In tetrahydrofuran; water; 1,2-dichloro-ethane; acetonitrile; 2: Stevens rearrangement;
DOI:10.1016/j.tetlet.2012.01.013

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 1363553-58-5
(2S)-N-(2-(4,5-dimethoxy-2-methylbenzylamino)pent-4-enoyl)-(1S,2R)-bornane-10,2-sultam

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen bromide; acetic acid / 12 h / 20 °C / Inert atmosphere

2: lithium chloride / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

3: tetrabutyl-ammonium chloride; sodium hydroxide / water; toluene / 72 h / 20 °C / Inert atmosphere

4: acetonitrile / 120 h / 20 °C / Inert atmosphere

5: potassium tert-butylate / tetrahydrofuran / 17 h / -40 °C / Inert atmosphere

6: 1,2-dichloro-ethane / 69 h / Reflux; Inert atmosphere

7: potassium dihydrogenphosphate; zinc / tetrahydrofuran; water / 7 h / 20 °C / Inert atmosphere

With potassium dihydrogenphosphate; potassium tert-butylate; tetrabutyl-ammonium chloride; hydrogen bromide; acetic acid; lithium chloride; sodium hydroxide; zinc; In tetrahydrofuran; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile; 5: Stevens rearrangement;
DOI:10.1016/j.tetlet.2012.01.013