1,2-Bis(chloromethyl)-4,5-dimethoxybenzene

Base Information

• Chemical Name: 1,2-Bis(chloromethyl)-4,5-dimethoxybenzene
• CAS No.: 1134-52-7
• Molecular Formula: C10H12Cl2O2
• Molecular Weight: 235.11
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID90449303
• Wikidata: Q82268720
• Mol file: 1134-52-7.mol

Synonyms:1134-52-7;1,2-bis(chloromethyl)-4,5-dimethoxybenzene;Benzene, 1,2-bis(chloromethyl)-4,5-dimethoxy-;1,2-dimethoxy-4,5-bis(chloromethyl)benzene;4,5-bischloromethyl veratrol;4,5-bis(chloromethyl)veratrol;SCHEMBL4042555;DTXSID90449303;HBOBUTXJMIXYPE-UHFFFAOYSA-N;AKOS028108836;D88132

Chemical Property of 1,2-Bis(chloromethyl)-4,5-dimethoxybenzene

Chemical Property:

• Melting Point: 85.5-86 °C
• Boiling Point: 325.7±37.0 °C(Predicted)
• PSA: 18.46000
• Density: 1.219±0.06 g/cm3(Predicted)
• LogP: 3.18140
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 234.0214350
• Heavy Atom Count: 14
• Complexity: 148

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C(=C1)CCl)CCl)OC

Technology Process of 1,2-Bis(chloromethyl)-4,5-dimethoxybenzene

There total 6 articles about 1,2-Bis(chloromethyl)-4,5-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,2-bis(bromomethyl)-4,5-dimethoxybenzene (26726-81-8) → 1,2-Dimethoxy-4,5-bis(chloromethyl)benzene (1134-52-7)

Guidance literature:

With lithium chloride; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.01.013

Reference yield: 83.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1,2-dimethoxybenzene (91-16-7) → 1,2-Dimethoxy-4,5-bis(chloromethyl)benzene (1134-52-7)

Guidance literature:

With hydrogenchloride; In water; methyl cyclohexane; at 60 ℃; for 8h;

DOI:10.1007/BF03246210

Reference yield: 10.0%

1,2-dimethoxybenzene (91-16-7) → 1,2-Dimethoxy-4,5-bis(chloromethyl)benzene (1134-52-7)

Guidance literature:

upstream raw materials:

1,2-dimethoxybenzene

formaldehyd

hydrogenchloride

1,2-bis(bromomethyl)-4,5-dimethoxybenzene

Downstream raw materials:

4,5-bisacetoxymethylveratrole

4,5-dimethoxy-phthalaldehyde

1,2-dimethoxy-4,5-dimethylbenzene

1,2-bisiodomethyl-4,5-dimethoxybenzene