(2S)-N-(2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)pent-4-enoyl)-(1S,2R)-bornane-10,2-sultam

Base Information

Chemical Name:(2S)-N-(2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)pent-4-enoyl)-(1S,2R)-bornane-10,2-sultam
CAS No.:1363553-57-4
Molecular Formula:C₂₈H₃₆Cl₄N₂O₇S
Molecular Weight:686.481
Hs Code.:

Synonyms:(2S)-N-(2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)pent-4-enoyl)-(1S,2R)-bornane-10,2-sultam

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-N-(2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)pent-4-enoyl)-(1S,2R)-bornane-10,2-sultam

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S)-N-(2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)pent-4-enoyl)-(1S,2R)-bornane-10,2-sultam

There total 5 articles about (2S)-N-(2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)pent-4-enoyl)-(1S,2R)-bornane-10,2-sultam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1363553-54-1
(2S)-N-(2-(5,6-dimethoxyisoindolin-2-yl))pent-4-enoyl-(1S,2R)-bornane-10,2-sultam

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 1363553-57-4
(2S)-N-(2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)pent-4-enoyl)-(1S,2R)-bornane-10,2-sultam

Guidance literature:: In 1,2-dichloro-ethane; for 69h; Reflux; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.01.013

Reference yield:

: 1363553-59-6
2-allyl-5,6-dimethoxyisoindoline

: 1363553-57-4
(2S)-N-(2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)pent-4-enoyl)-(1S,2R)-bornane-10,2-sultam

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 120 h / 20 °C / Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran / 17 h / -40 °C / Inert atmosphere

3: 1,2-dichloro-ethane / 69 h / Reflux; Inert atmosphere

With potassium tert-butylate; In tetrahydrofuran; 1,2-dichloro-ethane; acetonitrile; 2: Stevens rearrangement;
DOI:10.1016/j.tetlet.2012.01.013

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 1363553-57-4
(2S)-N-(2-((2-(chloromethyl)-4,5-dimethoxybenzyl)((2,2,2-trichloroethoxy)carbonyl)amino)pent-4-enoyl)-(1S,2R)-bornane-10,2-sultam

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen bromide; acetic acid / 12 h / 20 °C / Inert atmosphere

2: lithium chloride / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

3: tetrabutyl-ammonium chloride; sodium hydroxide / water; toluene / 72 h / 20 °C / Inert atmosphere

4: acetonitrile / 120 h / 20 °C / Inert atmosphere

5: potassium tert-butylate / tetrahydrofuran / 17 h / -40 °C / Inert atmosphere

6: 1,2-dichloro-ethane / 69 h / Reflux; Inert atmosphere

With potassium tert-butylate; tetrabutyl-ammonium chloride; hydrogen bromide; acetic acid; lithium chloride; sodium hydroxide; In tetrahydrofuran; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile; 5: Stevens rearrangement;
DOI:10.1016/j.tetlet.2012.01.013