Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, methyl ester (9CI)

Base Information

• Chemical Name: Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, methyl ester (9CI)
• CAS No.: 181283-75-0
• Molecular Formula: C9H8 N2 O3
• Molecular Weight: 192.17142
• Mol file: 181283-75-0.mol

Synonyms:Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, methyl ester (9CI)

Chemical Property of Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, methyl ester (9CI)

Chemical Property:

• PSA: 78.35000
• LogP: 1.77780
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

Methyl3-aminofuro[2,3-b]pyridine-2-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, methyl ester (9CI)

There total 3 articles about Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, methyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + glycolic acid methyl ester (96-35-5) → 3-amino-furo[2,3-b]pyridin-2-carboxylic acid methyl ester (181283-75-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; 1) -20 deg C, 4 h, 2) r.t., overnight;

DOI:10.1002/prac.199633801126

Reference yield: 13.0%

→ 3-amino-furo[2,3-b]pyridin-2-carboxylic acid methyl ester (181283-75-0)

Guidance literature:

Reference yield:

3-hydroxypyridine-2-carbonitrile (932-35-4) + ethyl bromoacetate (105-36-2) → 3-amino-furo[2,3-b]pyridin-2-carboxylic acid methyl ester (181283-75-0)

Guidance literature:

With pyridine; NaH; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

2-chloro-3-pyridinecarbonitrile

glycolic acid methyl ester

3-hydroxypyridine-2-carbonitrile

ethyl bromoacetate

Downstream raw materials:

methyl 3-(4-nitrobenzamido)furo[2,3-b]pyridine-2-carboxylate

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