2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-hydroxyl butyric acid benzyl ester

Base Information

Chemical Name:2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-hydroxyl butyric acid benzyl ester
CAS No.:1314863-94-9
Molecular Formula:C₂₉H₂₈N₂O₄
Molecular Weight:468.552
Hs Code.:

Synonyms:2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-hydroxyl butyric acid benzyl ester

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Chemical Property of 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-hydroxyl butyric acid benzyl ester

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Technology Process of 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-hydroxyl butyric acid benzyl ester

There total 8 articles about 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-hydroxyl butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1314863-84-7
2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-hydroxyl butyric Acid

: 100-39-0
benzyl bromide

: 1314863-94-9
2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-hydroxyl butyric acid benzyl ester

Guidance literature:: With potassium carbonate; In water; N,N-dimethyl-formamide; for 8h;
DOI:10.1016/j.bmcl.2011.05.034

Reference yield:

: 1314863-87-0
2,2-diphenyl-3-benzyloxy propionitrile

: 1314863-94-9
2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-hydroxyl butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / toluene / 0 - 20 °C / Inert atmosphere

2.1: sodium hydrogensulfite / tetrahydrofuran; water / 0.5 h / 20 °C

2.2: 20 °C

3.1: sulfuric acid / acetic acid / 22 h / 100 - 110 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h

4.2: 5 h / 90 °C

5.1: water; sodium hydroxide / methanol / 3 h / Reflux

6.1: potassium carbonate / water; N,N-dimethyl-formamide / 8 h

With sulfuric acid; water; diisobutylaluminium hydride; potassium carbonate; sodium hydrogensulfite; sodium hydroxide; In tetrahydrofuran; methanol; water; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmcl.2011.05.034

Reference yield:

: 1314863-88-1
2,2-diphenyl-3-benzyloxy propylaldehyde

: 1314863-94-9
2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl-4-hydroxyl butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogensulfite / tetrahydrofuran; water / 0.5 h / 20 °C

1.2: 20 °C

2.1: sulfuric acid / acetic acid / 22 h / 100 - 110 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h

3.2: 5 h / 90 °C

4.1: water; sodium hydroxide / methanol / 3 h / Reflux

5.1: potassium carbonate / water; N,N-dimethyl-formamide / 8 h

With sulfuric acid; water; potassium carbonate; sodium hydrogensulfite; sodium hydroxide; In tetrahydrofuran; methanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.05.034