N-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)methoxy)-N-methylacetamide

Base Information

• Chemical Name: N-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)methoxy)-N-methylacetamide
• CAS No.: 1327239-34-8
• Molecular Formula: C₁₄H₂₇NO₃
• Molecular Weight: 257.373

Synonyms:N-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)methoxy)-N-methylacetamide

Chemical Property of N-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)methoxy)-N-methylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)methoxy)-N-methylacetamide

There total 2 articles about N-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)methoxy)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2S,5R)-1-(chloromethoxy)-2-isopropyl-5-methylcyclohexane (26127-08-2,144177-48-0) + N-methylacetohydroxamic acid (13115-24-7) → N-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)methoxy)-N-methylacetamide (1327239-34-8)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 23 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ja205174c

Reference yield:

(-)-menthol (2216-51-5) → N-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)methoxy)-N-methylacetamide (1327239-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1: chloro-trimethyl-silane / 2 h / 23 °C / Inert atmosphere

2: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 0 - 23 °C / Inert atmosphere

With dmap; chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1021/ja205174c

Reference yield: 79.0%

N-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)methoxy)-N-methylacetamide (1327239-34-8) + potassium phenyltrifluoborate → [[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]methyl]benzene (136375-73-0)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1021/ja205174c

upstream raw materials:

(1R,2S,5R)-1-(chloromethoxy)-2-isopropyl-5-methylcyclohexane

N-methylacetohydroxamic acid

(-)-menthol

Downstream raw materials:

(1S,2R,4R)-1-isopropyl-4-methyl-2-((E)-undec-2-enyloxy)cyclohexane

[[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]methyl]benzene

1-Chloro-3-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)methyl)benzene

1-bromo-4-((((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)methyl)benzene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1327239-34-8 N-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)methoxy)-N-methylacetamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send