136375-73-0

Basic information

• Product Name: [[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]methyl]benzene
• Synonyms: [[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]methyl]benzene
• CAS NO: 136375-73-0
• Molecular Weight: 246.393
• Mol File: 136375-73-0.mol

Chemical Properties

• CAS DataBase Reference: [[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]methyl]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: [[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]methyl]benzene(136375-73-0)
• EPA Substance Registry System: [[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]methyl]benzene(136375-73-0)

Safety Data

• Hazardous Substances Data: 136375-73-0(Hazardous Substances Data)

Upstream product

• 2216-51-5 (-)-menthol 
• 100-39-0 benzyl bromide 
• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 
• 882980-43-0 2-benzyloxy-1-methylpyridinium triflate 
• 40864-08-2 2-benzyloxypyridine 
• 100-51-6 benzyl alcohol 
• 180477-54-7 (1S,2R,4R)-1-isopropyl-4-methyl-2-(3-methylbut-2-en-1-yloxy)cyclohexane 
• 195863-85-5 (1S,2R,4R)-1-isopropyl-4-methyl-2-(2-methylprop-2-en-1-yloxy)cyclohexane 
• 753488-83-4 (1S,2R,4R)-2-(2,3-dimethylbut-2-en-1-yloxy)-1-isopropyl-4-methylcyclohexane 
• 121153-32-0 (-)-menthol-MOM 
• 1327239-34-8 N-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)methoxy)-N-methylacetamide 
• 26127-08-2 (1R,2S,5R)-1-(chloromethoxy)-2-isopropyl-5-methylcyclohexane 
• 7285-83-8 2,4,6-tris(benzyloxy)-1,3,5-triazine 
• 18419-38-0 (-)-menthol trimethylsilyl ether 

Downstream Products

• 2216-51-5 (-)-menthol 
• 2623-23-6 L-menthyl acetate 
• 65-85-0 benzoic acid 
• 59632-78-9 (((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)oxy)dimethyl(phenyl)silane 
• 40940-58-7 (1S,2R,4R)-2-(allyloxy)-1-isopropyl-4-methylcyclohexane 
• 440122-04-3 α-azidobenzyl (-)-menthyl ether 
• 612-33-9 L-menthyl benzoate 
• 136289-27-5 (R)-1-[(R)-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-phenyl-methyl]-1,2-dihydro-naphthalene-1,4-dicarbonitrile 
• 136289-27-5 (R)-1-[(S)-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-phenyl-methyl]-1,2-dihydro-naphthalene-1,4-dicarbonitrile 

Relevant articles and documents

Development of triazine-based benzylating reagents possessing T-butyl group on the triazine core: Thermally controllable reagents for the initiation of reaction

Benzylating reagents, 4-(4,6-di-t-butyl-1,3,5-triazin-2-yl)-4-benzylmorpholinium triflate, and related derivatives have been developed. The reagents release benzyl triflate as a benzyl cation equivalent upon heating the solution to 40°C under neutral conditions. The O-benzylation of alcohols using a stoichiometric amount of these reagents afforded corresponding benzyl ethers in good to high yields. This was due to the presence of a bulky t-butyl group on the triazine ring of these reagents that prevents the consumption of benzyl triflate via a side reaction with a morpholinotriazine derivative.

N,N′-Dimethylated Benzyloxytriazinedione: A Stable Solid Reagent for Acid-Catalyzed O-Benzylation

N,N′-Dimethylated 6-(benzyloxy)-1,3,5-triazine-2,4(1H,3H)-dione (DMBOT) has been developed as a triazinedione-based, stable solid reagent for acid-catalyzed O-benzylation. The conceptual basis of the design was to fix the core triazinedione skeleton, and

TRIAZINE DIONE COMPOUND

PROBLEM TO BE SOLVED: To provide a novel triazine dione compound useful as an alkylating agent for a nucleophilic compound. SOLUTION: This invention relates to a compound represented by formula (I) [where each symbol is as defined in the specification] and an alkylating agent comprising the compound, and a method for alkylating a nucleophilic compound using the alkylating agent. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

Vanadium-Catalyzed Oxidative Debenzylation of O-Benzyl Ethers at ppm Level

An advantageous methodology for the oxidative debenzylation of ethers has been developed. Very low amounts of a catalyst system based on vanadyl acetylacetonate and a triazole type pincer ligand allow the selective oxidative cleavage of a number of O-benzyl ethers in the presence of oxygen as the sole oxidant. The methodology tolerates a number of functional groups such as halo-, alkoxy-, or trifluoromethylarenes, alkyne, alkene, ether, and acetal units. Large-scale deprotections can be also carried out by the optimized procedure, which is amenable to enantioenriched reactants as well. (Figure presented.).

Triazine compound

PROBLEM TO BE SOLVED: To provide a novel triazine compound useful as an agent for arylmethylating a nucleophilic compound. SOLUTION: This invention relates to a compound represented by formula (I) [where each symbol is as defined in the specification], an

Redox-Active Esters in Fe-Catalyzed C-C Coupling

Cross-couplings of alkyl halides and organometallic species based on single electron transfer using Ni and Fe catalyst systems have been studied extensively, and separately, for decades. Here we demonstrate the first couplings of redox-active esters (both isolated and derived in situ from carboxylic acids) with organozinc and organomagnesium species using an Fe-based catalyst system originally developed for alkyl halides. This work is placed in context by showing a direct comparison with a Ni catalyst for >40 examples spanning a range of primary, secondary, and tertiary substrates. This new C-C coupling is scalable and sustainable, and it exhibits a number of clear advantages in several cases over its Ni-based counterpart.

Synthesis of ethers from carbonyl compounds by reductive etherification catalyzed by iron(III) and silyl chloride

A simple iron- and silyl chloride catalyzed method for the preparation of symmetrical and nonsymmetrical ethers is presented. Various aldehydes and ketones were reductively etherified by using triethylsilane as a reducing agent in the presence of 2 mol% of iron(III) oxo acetate and 8 mol% of chloro(trimethyl)silane. The reactions can be carried out at ambient temperatures and pressures with ethyl acetate as the solvent.

Gold(I)-catalyzed synthesis of unsymmetrical ethers using alcohols as alkylating reagents

A microwave-irradiated alcohol-protecting strategy based on gold catalysis utilizing benzyl alcohol, tert-butyl alcohol and triphenylmethanol as alkylating reagents has been developed. This protecting strategy has wide functional group tolerance with satisfactory yields for the majority of the selected alcohols. The mechanism of this transformation was probed with oxygen-18 isotope labelled alcohols assisted by GC-MS techniques and chemical kinetic experiments. This strategy provides an efficient, straightforward and alternative approach to the preparation of benzyl, tert-butyl and trityl ethers in organic synthesis.

Development of a new benzylating reagent spontaneously releasing benzyl cation equivalents at room temperature

A new O-benzylating reagent, that is, 4-(4,6-diphenoxy-1,3,5-triazin-2-yl)-4-benzylmorpholinium trifluoromethanesulfonate (DPT-BM), has been developed. Benzyl cation equivalents are generated from DPT-BM by dissolving the compound in a solvent at room tem

Benzylation of hydroxy groups with tertiary amine as a base

The benzylation of hydroxy groups in the presence of tertiary amines is described. A mixture of an alcohol and a benzyl halide afforded the corresponding benzyl ether in good to excellent yields in the presence of diisopropylethylamine. The importance of solventless conditions was observed. The reaction showed high tolerance to many functional groups including benzoate, even at a reaction temperature of 150 °C. Sodium iodide was found to be an efficient catalyst to accelerate the reaction.